Evidence map›Paper›PMID 29481320›Full record

SynthesisJournal of psychiatry & neuroscience : JPN2018

Association between structural and functional brain alterations in drug-free patients with schizophrenia: a multimodal meta-analysis.

Xin Gao, Wenjing Zhang, Li Yao, Yuan Xiao, Lu Liu, Jieke Liu, Siyi Li, Bo Tao, Chandan Shah, Qiyong Gong and 2 more

Abstract readMeta-Analysis
PubMed Full text at PMC
In one paragraph

Synthesis in Journal of psychiatry & neuroscience : JPN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  4. Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea.European archives of psychiatry and clinical neuroscience · 2023
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  18. Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xin GaoFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Wenjing ZhangFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Li YaoFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Yuan XiaoFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Lu LiuFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Jieke LiuFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Siyi LiFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Bo TaoFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Chandan ShahFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Qiyong GongFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
John A SweeneyFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).
Su LuiFrom the Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (Gao, Lui); the Department of Radiology, the Centre for Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Gao, Zhang, Yao, Xiao, Liu, Li, Tao, Shah, Gong, Lui); and the Department of Psychiatry, University of Texas Southwestern, Dallas, Tex, USA (Sweeney).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroimaging studies have shown both structural and functional abnormalities in patients with schizophrenia. Recently, studies have begun to explore the association between structural and functional grey matter abnormalities. By conducting a meta-analysis on morphometric and functional imaging studies of grey matter alterations in drug-free patients, the present study aims to examine the degree of overlap between brain regions with anatomic and functional changes in patients with schizophrenia.

methodsWe performed a systematic search of PubMed, Embase, Web of Science and the Cochrane Library to identify relevant publications. A multimodal analysis was then conducted using Seed-based d Mapping software. Exploratory analyses included jackknife, subgroup and meta-regression analyses.

resultsWe included 15 structural MRI studies comprising 486 drug-free patients and 485 healthy controls, and 16 functional MRI studies comprising 403 drug-free patients and 428 controls in our meta-analysis. Drug-free patients were examined to reduce pharmacological effects on the imaging data. Multimodal analysis showed considerable overlap between anatomic and functional changes, mainly in frontotemporal regions, bilateral medial posterior cingulate/paracingulate gyrus, bilateral insula, basal ganglia and left cerebellum. There were also brain regions showing only anatomic changes in the right superior frontal gyrus, left supramarginal gyrus, right lingual gyrus and functional alternations involving the right angular gyrus. LIMITATIONS: The methodological aspects, patient characteristics and clinical variables of the included studies were heterogeneous, and we cannot exclude medication effects.

conclusionThe present study showed overlapping anatomic and functional brain abnormalities mainly in the default mode (DMN) and auditory networks (AN) in drug-free patients with schizophrenia. However, the pattern of changes differed in these networks. Decreased grey matter was associated with decreased activation within the DMN, whereas it was associated with increased activation within the AN. These discrete patterns suggest different pathophysiological changes impacting structural and functional associations within different neural networks in patients with schizophrenia.

Indexed as

BrainGray MatterHumansMagnetic Resonance ImagingMultimodal ImagingNeural PathwaysNeuroimagingSchizophrenia

Identifiers

PMID29481320
PMCPMC5837885

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.