ArticleJournal of psychiatry & neuroscience : JPN2018
Greater body mass index is associated with reduced frontal cortical volumes among adolescents with bipolar disorder.
Article in Journal of psychiatry & neuroscience : JPN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain structural and functional changes in childhood and adolescent obesity: a systematic review of MRI studies.Frontiers in human neuroscience · 2026Pooled it
- The impact of body mass index on the clinical features of bipolar disorder: A STEP-BD study.Bipolar disorders · 2024Article
- Higher Levels of C-reactive Protein Are Associated With Higher Cortical Surface Area and Lower Cortical Thickness in Youth With Bipolar Disorder.The international journal of neuropsychopharmacology · 2023Article
- Article
- Article
- Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals.Bipolar disorders · 2022Article
- Obesity and Cerebral Blood Flow in the Reward Circuitry of Youth With Bipolar Disorder.The international journal of neuropsychopharmacology · 2022Article
- Neurostructural correlates of retinal microvascular caliber in adolescent bipolar disorder.JCPP advances · 2021Article
- Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.Molecular psychiatry · 2021Article
- Brain Functional and Structural Alterations in Women With Bipolar Disorder and Suicidality.Frontiers in psychiatry · 2021Article
- Call to action regarding the vascular-bipolar link: A report from the Vascular Task Force of the International Society for Bipolar Disorders.Bipolar disorders · 2020Review
- Higher Body-Mass Index and Lower Gray Matter Volumes in First Episode of Psychosis.Frontiers in psychiatry · 2020Article
- Evidence that genes involved in hedgehog signaling are associated with both bipolar disorder and high BMI.Translational psychiatry · 2019Article
- Elevated Familial Cardiovascular Burden Among Adolescents With Familial Bipolar Disorder.Frontiers in psychiatry · 2019Article
- Who should be "controls" in studies on the neurobiology of psychiatric disorders?Journal of psychiatry & neuroscience : JPN · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundHigher body mass index (BMI) and obesity is common among youth with bipolar disorder (BD) and is associated with greater psychiatric illness severity, including suicidality. Obesity has been associated with frontal, temporal and subcortical volumetric reductions in adults with BD. We examined the neurostructural correlates of BMI in adolescents early in their course of BD.
methodsWe processed
resultsWe included 40 adolescents with BD and 48 controls in our analyses. In addition to a main effect of BMI on the ROIs, there were significant diagnosis × BMI interaction effects on FL volumes. In the BD group only, BMI was negatively associated with FL, OFC and PFC cortical thickness. Whole brain analysis of BMI-volume correlations revealed 2 significant interaction clusters: 1 in the medial OFC and 1 in the caudal anterior cingulate cortex, with BD showing a stronger negative correlation. LIMITATIONS: Reliance on BMI rather than a more nuanced measure of obesity may have influenced the findings.
conclusionOur results suggest that elevated BMI among adolescents with BD is associated with frontal neurostructural differences that are not observed in controls. Prospective studies examining the direction of the observed associations and the effect of BMI optimization on brain structure in adolescents with BD are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.