ArticleBioelectronics in medicine2018
Calibration of thresholds for functional engagement of vagal A, B and C fiber groups
Article in Bioelectronics in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Vagus nerve stimulation as a potential treatment for acute asthmatic bronchoconstriction: a systematic review.Frontiers in physiology · 2025Pooled it
- Bursting Parameters Alter Excitatory Postsynaptic Currents in Nucleus Tractus Solitarius Neurons: Implications for Clinical Vagus Nerve Stimulation.Journal of neurochemistry · 2026Article
- Asymmetric tripolar nerve cuff electrode designs for optimizing anodal block of myelinated fibers.Biomedical engineering online · 2026Article
- A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action.Comprehensive physiology · 2026Review
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- The vagus nerve as a neurovisceral interface: a comprehensive review.Frontiers in neuroscience · 2026Review
- The effect of vagus nerve stimulation on heart rate and respiration rate and their impact on seizure susceptibility in anaesthetized rats under pentylenetetrazol.Frontiers in neuroscience · 2025Article
- Using neural biomarkers to personalize dosing of vagus nerve stimulation.Bioelectronic medicine · 2024Article
- Fractal Microelectrodes for More Energy-Efficient Cervical Vagus Nerve Stimulation.Advanced healthcare materials · 2023Article
- Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans.Journal of neural engineering · 2023Article
- Flexible IrOActa biomaterialia · 2023Article
- Vagus nerve stimulation parameters evoke differential neuronal responses in the locus coeruleus.Physiological reports · 2023Article
- Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect.Journal of neural engineering · 2023Article
- Feasibility of transesophageal phrenic nerve stimulation.Biomedical engineering online · 2023Article
- A combined cuff electrode array for organ-specific selective stimulation of vagus nerve enabled by Electrical Impedance Tomography.Frontiers in medical technology · 2023Article
- In vivo peripheral nerve activation using sinusoidal low-frequency alternating currents.Artificial organs · 2022Article
- Short-pulsed micro-magnetic stimulation of the vagus nerve.Frontiers in physiology · 2022Article
- Abdominal vagus nerve stimulation alleviates collagen-induced arthritis in rats.Frontiers in neuroscience · 2022Article
- A flexible protruding microelectrode array for neural interfacing in bioelectronic medicine.Microsystems & nanoengineering · 2022Article
- Closed-loop automated reaching apparatus (CLARA) for interrogating complex motor behaviors.Journal of neural engineering · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Vagal nerve stimulation is widely used therapeutically but the fiber groups activated are often unknown.
aimTo establish a simple protocol to define stimulus thresholds for vagal A, B and C fibers.
methodsThe intact left or right cervical vagus was stimulated with 0.1 ms pulses in spontaneously breathing anesthetized rats. Heart and respiratory rate responses to vagal stimulation were recorded. The vagus was subsequently cut distally, and mass action potentials to the same stimuli were recorded.
resultsStimulating at either 50 Hz for 2 s or 2 Hz for 10 s at experimentally determined strengths revealed A, B and C fiber thresholds that were related to respiratory and heart rate changes.
conclusionOur simple protocol discriminates vagal A, B and C fiber thresholds
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