Evidence map›Paper›PMID 29480897›Full record

ReviewBioelectronics in medicine2018

Reversible conduction block in peripheral nerve using electrical waveforms.

Niloy Bhadra, Tina L Vrabec, Narendra Bhadra, Kevin L Kilgore

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Bioelectronics in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06868342 (Determination of Feasibility of Reversible Conduction Block Generated Using Peripheral Nerve Stimulator in Treatment of Focal Spasticity and the Stimulation Parameters for the Same.), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06868342 nacompletednot on this mapstarted 2024, after this paper: background citation

Determination of Feasibility of Reversible Conduction Block Generated Using Peripheral Nerve Stimulator in Treatment of Focal Spasticity and the Stimulation Parameters for the Same.

TypeinterventionalSponsorWalton Centre NHS Foundation TrustRan2024 to 2024Enrolled4ConditionsSpasticity, Spasticity in Participants With Multiple Sclerosis, Spasticity Post Stroke, Spasticity Related to Any Cause Except Cerebral PalsyArmsHigh-frequency nerve conduction block
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Fuzzy Logic Control of Heartrate by Electrical Block of Vagus Nerve.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Niloy BhadraDepartment of Physical Medicine & Rehabilitation, MetroHealth Medical Center, Cleveland, OH 44109, USA.
Tina L VrabecDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Narendra BhadraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Kevin L KilgoreDepartment of Orthopaedics, MetroHealth Medical Center & Case Western Reserve University, Cleveland, OH 44109, USA.
MetroHealth Medical Center · USCase Western Reserve University · USLouis Stokes Cleveland VA Medical Center · US

Funding

A Novel Waveform for Electrical Nerve Conduction BlockR01EB002091 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI KILGORE, KEVIN L. · 2003 to 2010
$2.6M
Separated-interface Electrodes for use with High Frequency Nerve Conduction BlockR01NS074149 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI BHADRA, NARENDRA · 2011 to 2014
$1.4M
NIBIB NIH HHS R01 EB002091NINDS NIH HHS R01 NS074149
6 · The paper itself

Abstract

introductionElectrical nerve block uses electrical waveforms to block action potential propagation. MATERIALS &

methodsTwo key features that distinguish electrical nerve block from other nonelectrical means of nerve block: block occurs instantly, typically within 1 s; and block is fully and rapidly reversible (within seconds).

resultsApproaches for achieving electrical nerve block are reviewed, including kilohertz frequency alternating current and charge-balanced polarizing current. We conclude with a discussion of the future directions of electrical nerve block.

conclusionElectrical nerve block is an emerging technique that has many significant advantages over other methods of nerve block. This field is still in its infancy, but a significant expansion in the clinical application of this technique is expected in the coming years.

Indexed as

action potentialdirect currentelectrical nerve blockkilohertz frequencyneuromodulationneuroprosthesis

Identifiers

PMID29480897
PMCPMC5811084
OpenAlexW2772275065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.