Evidence map›Paper›PMID 29480894›Full record

ArticleNature medicine2018

Restorative effects of human neural stem cell grafts on the primate spinal cord.

Ephron S Rosenzweig, John H Brock, Paul Lu, Hiromi Kumamaru, Ernesto A Salegio, Ken Kadoya, Janet L Weber, Justine J Liang, Rod Moseanko, Stephanie Hawbecker and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed, 3 pooled it
20.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

203 citing papers in PubMed, 3 syntheses or guidelines pooled it, 358 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Transcriptomics Insights into Spinal Cord Injury for Therapy Development.International journal of molecular sciences · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Repurposing of Chemokine Antagonists for Combined Phase-Resolved Spinal Cord Injury Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Ephron S RosenzweigDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
John H BrockDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Paul LuDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Hiromi KumamaruDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Ernesto A SalegioCalifornia National Primate Research Center, University of California, Davis, Davis, California, USA.
Ken KadoyaDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Janet L WeberDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Justine J LiangDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Rod MoseankoCalifornia National Primate Research Center, University of California, Davis, Davis, California, USA.
Stephanie HawbeckerCalifornia National Primate Research Center, University of California, Davis, Davis, California, USA.
J Russell HuieDepartment of Neurosurgery, University of California, San Francisco, San Francisco, California, USA.
Leif A HavtonDepartment of Neurology, University of California, Los Angeles, Los Angeles, California, USA.
Yvette S Nout-LomasCollege of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0001-6583-2308
Adam R FergusonDepartment of Neurosurgery, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-7102-1608
Michael S BeattieDepartment of Neurosurgery, University of California, San Francisco, San Francisco, California, USA.
Jacqueline C BresnahanDepartment of Neurosurgery, University of California, San Francisco, San Francisco, California, USA.
Mark H TuszynskiDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
University of California San Diego · USUnited States Department of Veterans Affairs · USUniversity of California, Davis · USUniversity of California, San Francisco · USColorado State University · USHokkaido University · JPSan Francisco VA Medical Center · USUniversity of California, Los Angeles · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Plasticity and Regeneration in the Primate Spinal CordR01NS042291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRESNAHAN, JACQUELINE C, CAPITANIO, JOHN P · 2001 to 2015
$13.0M
The Primate Corticospinal Connectome and Transcriptome - SupplementR01NS104442 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUSZYNSKI, MARK H. · 2017 to 2025
$5.7M
Embryonic stem cell therapy after cervical contusion SCI in NHPsR01NS105478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2017 to 2021
$2.9M
Plasticity and Regeneration in the Primate Spinal CordR56NS042291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2017 to 2017
$543k
SCI Consortium Study: Harnessing big-data for plasticity and rehabilitation in translational SCII01RX002245 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI ADAM R FERGUSON · 2017 to 2026
–
Transplantation of Human Neural Stem Cells for Treatment of Chronic SCII01RX001045 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI BROCK, JOHN H. · 2014 to 2016
–
NIH HHS P51 OD011107NINDS NIH HHS R01 NS042291NINDS NIH HHS R01 NS104442NINDS NIH HHS R01 NS105478NINDS NIH HHS R56 NS042291RRD VA I01 RX001045RRD VA I01 RX002245
6 · The paper itself

Abstract

We grafted human spinal cord-derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and improved forelimb function beginning several months after grafting. These findings in a 'preclinical trial' support translation of NPC graft therapy to humans with the objective of reconstituting both a neuronal and glial milieu in the site of spinal cord injury.

Indexed as

Nerve RegenerationAnimalsAxonsCell DifferentiationCell MovementCell SurvivalHumansMacaca mulattaMagnetic Resonance ImagingMaleNeural Stem CellsSpinal CordTreatment Outcome

Identifiers

PMID29480894
PMCPMC5922761
OpenAlexW2790049490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.