Evidence map›Paper›PMID 29480796›Full record

ArticleBioMedicine2018

The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM).

Jai-Sing Yang, Yan-Ru Peng, Shih-Chang Tsai, Yeu-Sheng Tyan, Chi-Cheng Lu, Hong-Yi Chiu, Yu-Jen Chiu, Sheng-Chu Kuo, Yuh-Feng Tsai, Ping-Chin Lin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jai-Sing YangDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Yan-Ru PengSchool of Medicine, China Medical University, Taichung 404, Taiwan.
Shih-Chang TsaiDepartment of Biological Science and Technology, China Medical University, Taichung 404, Taiwan.
Yeu-Sheng TyanDepartment of Medical Imaging, Chung Shan Medical University Hospital, Taichung 402, Taiwan - School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 402, Taiwan - School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
Chi-Cheng LuDepartment of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan.
Hong-Yi ChiuDepartment of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan.
Yu-Jen ChiuDivision of Reconstructive and Plastic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Sheng-Chu KuoChinese Medicinal Research and Development Center, China Medical University Hospital, China Medical University, Taichung 404, Taiwan - School of Pharmacy, China Medical University, Taichung 404, Taiwan.
Yuh-Feng TsaiDepartment of Diagnostic Radiology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan - School of Medicine, Fu-Jen Catholic University, Taipei 242, Taiwan.
Ping-Chin LinDepartment of Medical Imaging, Chia-Yi Christian Hospital, Chiayi 600, Taiwan.
Fuu-Jen TsaiGenetics Center, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan - School of Chinese Medicine, China Medical University, Taichung 404, Taiwan - Department of Medical Genetics, China Medical University Hospital, Taichung 404, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iodinated contrast media (iodinated CM) have increased ability to absorb x-rays and to visualize structures that normally are impossible to observe in a radiological examination. The use of iodinated CM may destory renal function, commonly known as contrast-induced nephropathy (CIN), which can result in acute renal failure (ARF). This review article mainly focuses on the following areas: (1) classifications of iodinated CM: ionic or non-ionic, high-osmolarity contrast media (HOCM), low-osmolarity contrast media (LOCM) and iso-osmolarity contrast media (IOCM); (2) an introduction to the physical and chemical properties of the non-ionic iodinated CM; (3) the management of anaphylactic reaction by iodinated CM; (4) a suggested single injection of adult doses and maximum dose for non-ionic iodinated CM; (5) the molecular mechanism of contrast-induced nephropathy (CIN); (6) In vitro studies on iodinated CM. Based on above information, this review article provide an insight for understanding the drug safety of iodinated CM.

Identifiers

PMID29480796
PMCPMC5826038

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.