ArticleClinical cardiology2018
NT-proBNP is associated with mortality and adverse cardiac events in patients with atrial fibrillation presenting to the emergency department.
Article in Clinical cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Refining risk prediction in geriatric heart failure: the emergency heart failure mortality risk grade‑BI model under scrutiny.Aging clinical and experimental research · 2026Article
- Development and validation of an interpretable machine learning model for predicting 5-year major adverse cardiovascular events in patients with coronary artery disease.BMC cardiovascular disorders · 2026Article
- Article
- Clinical and Proteomic Associations of SARS-CoV-2 Infection and COVID-19 Vaccination in Multimorbid Patients: A Cross-Sectional Observational Study.International journal of molecular sciences · 2025Observational
- Correlation between triglyceride-glucose index and atrial fibrillation in acute coronary syndrome patients: a retrospective cohort study and the establishment of a LASSO-Logistic regression model.BMC cardiovascular disorders · 2024Article
- Development and validation of a nomogram model for all-cause mortality risk in patients with chronic heart failure and atrial fibrillation.BMC geriatrics · 2024Article
- Diagnostic and Prognostic Value of Aminoterminal Prohormone of Brain Natriuretic Peptide in Heart Failure with Mildly Reduced Ejection Fraction Stratified by the Degree of Renal Dysfunction.Journal of clinical medicine · 2024Article
- Atrial Fibrillation, thromboembolic risk, and the potential role of the natriuretic peptides, a focus on BNP and NT-proBNP - A narrative review.International journal of cardiology. Heart & vasculature · 2022Review
- Natriuretic peptides: biomarkers for atrial fibrillation management.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Review
- NT-proBNP is associated with mortality and adverse cardiac events in patients with atrial fibrillation presenting to the emergency department.Clinical cardiology · 2018Article
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5 authors.
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Abstract
backgroundAtrial fibrillation (AF) is the most common cardiac arrhythmia in the emergency department. The CHA HYPOTHESIS: The biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) has prognostic value in patients presenting to the emergency department with AF.
methodsDuring a 1.5-year period, a prospective study was performed in consecutive patients presenting to the emergency department with AF on the presenting electrocardiogram. At baseline, NT-proBNP was measured. The primary endpoints were all-cause death and major adverse cardiac events (MACE: all-cause mortality, myocardial infarction, or revascularization).
resultsA total of 355 patients were included (mean age, 71 years; 55% male). The median duration of follow-up was 2 years. After adjustment for baseline variables, the logNT-proBNP was independently correlated with death (hazard ratio [HR]: 1.54, 95% confidence interval [CI]: 1.18-1.99) and MACE (HR: 1.27, 95% CI: 1.03-1.58). After adjustment for baseline variables, a high NT-proBNP value (>500 pmol/L) was independently correlated with death (HR: 2.26, 95% CI: 1.19-4.28), and for MACE a trend was seen (HR: 1.67, 95% CI: 0.96-2.91) compared with a low value (<250 pmol/L).
conclusionsIn patients presenting to the emergency department with AF, higher NT-proBNP values are independently associated with an increased mortality and MACE. Therefore, this biomarker may be a useful prognostic marker in the management and treatment of these patients.
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