Evidence map›Paper›PMID 29480337›Full record

ReviewWorld journal of microbiology & biotechnology2018

Recent advances in microbial production of mannitol: utilization of low-cost substrates, strain development and regulation strategies.

Min Zhang, Lei Gu, Chao Cheng, Jiangfeng Ma, Fengxue Xin, Junli Liu, Hao Wu, Min Jiang

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Causal Relationship Between Gut Microbiota, Metabolites, and Sarcopenia: A Mendelian Randomization Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  5. Sugar Alcohol Sweetener Production byMolecules (Basel, Switzerland) · 2023
    Article
  6. Characterization of Two Mannitol-ProducingJournal of microbiology and biotechnology · 2023
    Article
  7. Honey's Yeast-New Source of Valuable Species for Industrial Applications.International journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Engineering the oleaginous yeastBiotechnology for biofuels · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Min ZhangCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China.
Lei GuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China.
Chao ChengCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China.
Jiangfeng MaCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China.
Fengxue XinCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China.
Junli LiuInstitute of Chemical Industry of Forest Products, Nanjing, 210042, People's Republic of China.
Hao WuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China.
Min JiangCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People's Republic of China. bioengine@njtech.edu.cn.
Nanjing Tech University · CNInstitute of Chemical Industry of Forest Products · CN

Funding

Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Foundation JSBEM2016010The Key Science and Technology Project of Jiangsu Province BE2016389
6 · The paper itself

Abstract

Mannitol has been widely used in fine chemicals, pharmaceutical industries, as well as functional foods due to its excellent characteristics, such as antioxidant protecting, regulation of osmotic pressure and non-metabolizable feature. Mannitol can be naturally produced by microorganisms. Compared with chemical manufacturing, microbial production of mannitol provides high yield and convenience in products separation; however the fermentative process has not been widely adopted yet. A major obstacle to microbial production of mannitol under industrial-scale lies in the low economical efficiency, owing to the high cost of fermentation medium, leakage of fructose, low mannitol productivity. In this review, recent advances in improving the economical efficiency of microbial production of mannitol were reviewed, including utilization of low-cost substrates, strain development for high mannitol yield and process regulation strategies for high productivity.

Indexed as

Costs and Cost AnalysisFermentationIndustrial MicrobiologyBacteriaBiotechnologyCell Culture TechniquesCulture MediaFructoseGenetic EngineeringMannitolMetabolic Flux AnalysisYeastsCulture MediaFructoseMannitolFermentationMannitolMetabolic fluxRegulationStrain development

Identifiers

PMID29480337
OpenAlexW2790047195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.