Evidence map›Paper›PMID 29480295›Full record

ArticleNanoscale2018

Unexpected insights into antibacterial activity of zinc oxide nanoparticles against methicillin resistant Staphylococcus aureus (MRSA).

Usha Kadiyala, Emine Sumeyra Turali-Emre, Joong Hwan Bahng, Nicholas A Kotov, J Scott VanEpps

Abstract read
In one paragraph

Article in Nanoscale, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 278 citations in OpenAlex.

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  10. Design and characterization of SrONaunyn-Schmiedeberg's archives of pharmacology · 2026
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  19. Nanoarchitectonics for synergistic activity of multimetallic nanohybrids as a possible approach for antimicrobial resistance (AMR).Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Review
  20. Review

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Usha KadiyalaDepartment of Emergency Medicine, University of Michigan, Ann Arbor, USA. jvane@med.umich.edu.
Emine Sumeyra Turali-Emre
Joong Hwan Bahng
Nicholas A Kotov
J Scott VanEpps
University of Michigan · US

Funding

Biomechanics of Blood Stream InfectionsR01GM081702 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOLOMON, MICHAEL J · 2009 to 2017
$3.2M
Antimicrobial mechanisms of action zinc oxide nanoparticlesK08AI128006 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VANEPPS, J SCOTT · 2017 to 2020
$778k
NIAID NIH HHS K08 AI128006NIGMS NIH HHS R01 GM081702
6 · The paper itself

Abstract

Zinc oxide nanoparticles (ZnO-NPs) are attractive as broad-spectrum antibiotics, however, their further engineering as antimicrobial agents and clinical translation is impeded by controversial data about their mechanism of activity. It is commonly reported that ZnO-NP's antimicrobial activity is associated with the production of reactive oxygen species (ROS). Here we disprove this concept by comparing the antibacterial potency of ZnO-NPs and their capacity to generate ROS with hydrogen peroxide (H

Indexed as

Metal NanoparticlesAnti-Bacterial AgentsHydrogen PeroxideMethicillin-Resistant Staphylococcus aureusZinc OxideAnti-Bacterial AgentsHydrogen PeroxideZinc Oxide

Identifiers

PMID29480295
PMCPMC5847298
OpenAlexW2788482535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.