Evidence map›Paper›PMID 29480186›Full record

SynthesisJournal of Alzheimer's disease : JAD2018

Meta-Analysis of Personality Traits in Alzheimer's Disease: A Comparison with Healthy Subjects.

Alfonsina D'Iorio, Federica Garramone, Fausta Piscopo, Chiara Baiano, Simona Raimo, Gabriella Santangelo

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. Association of Personality Traits with Life and Work of Medical Students: An Integrative Review.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alfonsina D'IorioDepartment of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Federica GarramoneDepartment of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Fausta PiscopoDepartment of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Chiara BaianoDepartment of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Simona RaimoDepartment of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Gabriella SantangeloDepartment of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of specific personality traits as factor risks of Alzheimer's disease (AD) has been consistently found, whereas personality traits specifically related to AD (after the diagnosis) have not been outlined yet.

objectiveA meta-analysis of published studies was performed to determine whether AD patients have a distinctive personality trait profile compared to healthy subjects (HC), similar to or different from a premorbid personality profile consistently reported in previous studies.

methodsA systematic literature search was performed using PsycInfo (PROQUEST), PubMed, and Scopus. The meta-analysis pooled results from primary studies using Hedges' g unbiased approach.

resultsThe meta-analysis included 10 primary studies and revealed that, when the personality was evaluated by informant-rated measures, AD patients had significantly higher levels of Neuroticism, lower levels of Openness, Agreeableness, Conscientiousness, and Extraversion than HCs. When the personality was evaluated by self-rated measures, the results obtained from informants were confirmed for Neuroticism, Openness, and Extraversion but not for Agreeableness and Conscientiousness where AD patients and HCs achieved similar scores.

conclusionsThe meta-analysis revealed that high Neuroticism and low Openness and Extraversion are distinctive personality traits significantly associated with a diagnosis of AD when evaluated both self-rated and informant-rated measures. This personality trait profile is similar to premorbid one, which contributes to development of AD over time. Therefore, our findings indirectly support the idea of specific premorbid personality traits as harbingers of AD.

Indexed as

PersonalityAlzheimer DiseaseCase-Control StudiesHumansPersonality InventoryAlzheimer’s diseasedementiafactor riskneuroticismpersonality

Identifiers

PMID29480186
PMCPMC5842787

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.