ArticleJournal of diabetes investigation2018
Positive association of plasma leptin with sleep quality in obese type 2 diabetes patients.
Article in Journal of diabetes investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Crosstalk between sleep disorders and adipokine secretory profiles: novel mechanisms for metabolic disease risk.Annals of medicine · 2026Review
- Association Between Glucocorticoid Exposure and Objective Sleep Architecture in Rheumatoid Arthritis: An Exploratory Pilot EEG Study.Journal of clinical medicine · 2026Article
- Temporal dynamics and associated factors of sleep quality in Chinese boarding high school students: a repeated cross-sectional study across four waves (2019-2024).Scientific reports · 2026Article
- The relationship between frailty and multimorbidity in Chinese older adults: the chain mediating effects of sleep quality and anxiety.BMC geriatrics · 2025Article
- A biological rhythm in the hypothalamic system links sleep-wake cycles with feeding-fasting cycles.Scientific reports · 2024Article
- The relations of circulating agouti-related peptide and leptin with altered sleep architecture in patients with active Cushing's disease: a pilot study.Journal of endocrinological investigation · 2024Article
- Impact of Body Composition on Sleep and Its Relationship with Sleep Disorders: Current Insights.Nature and science of sleep · 2023Review
- Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines.International journal of molecular sciences · 2022Review
- Leptin and adiponectin regulate the activity of nuclei involved in sleep-wake cycle in male rats.Frontiers in neuroscience · 2022Article
- The Role of Sleep Curtailment on Leptin Levels in Obesity and Diabetes Mellitus.Obesity facts · 2021Review
- Obesity, metabolic syndrome and bariatric surgery: A narrative review.Journal of diabetes investigation · 2020Review
- Improvement of glycemic control by treatment for insomnia with suvorexant in type 2 diabetes mellitus.Journal of clinical & translational endocrinology · 2019Article
- [Importance of sleep and circadian rhythm for energy metabolism].Der Internist · 2019Review
- Positive association of plasma leptin with sleep quality in obese type 2 diabetes patients.Journal of diabetes investigation · 2018Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
AIMS/
introductionPoor sleep quality is associated with obesity and diabetes. The adipocyte-derived hormone, leptin, was recently shown to underlie the link between abnormal sleep and obesity. We aimed to investigate the association between leptin and sleep quality in type 2 diabetes patients. MATERIALS AND
methodsIn the present cross-sectional study, we studied 182 type 2 diabetes patients, among whom 113 were diagnosed with obesity (body mass index ≥25 kg/m
resultsUsing unadjusted analyses, the obese type 2 diabetes patients, but not their non-obese counterparts, showed a positive correlation between plasma leptin levels and a parameter for deep sleep assessed by delta power during the first sleep cycle. Multivariate analysis showed that plasma leptin levels were positively associated with delta power, but not with the total sleep time, after adjusting for potential confounders including age, body mass index and the apnea-hypopnea index, in the obesity group. However, neither delta power nor total sleep time was associated with leptin in the non-obesity group.
conclusionsPlasma leptin levels are independently associated with sleep quality in obese, but not in non-obese, type 2 diabetes patients. The present study indicates a favorable relationship between leptin and sleep quality in obese type 2 diabetes patients.
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