Evidence map›Paper›PMID 29479825›Full record

ArticleCNS neuroscience & therapeutics2018

Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence.

Francis Delicata, Cristiano Bombardi, Massimo Pierucci, Roberto Di Maio, Philippe De Deurwaerdère, Giuseppe Di Giovanni

Open access · bronzeAbstract read
In one paragraph

Article in CNS neuroscience & therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Preferential Modulatory Action of 5-HTThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  4. Review
  5. Lateral Habenula 5-HTInternational journal of molecular sciences · 2021
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 5 countries.

Francis DelicataDepartment of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Cristiano BombardiDipartimento di Scienze Mediche Veterinarie, Università di Bologna, Bologna, Italia.
Massimo PierucciDepartment of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Roberto Di MaioPittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA.
Philippe De DeurwaerdèreCentre National de la Recherche Scientifique (Unité Mixte de Recherche 5287), Bordeaux Cedex, France.ORCID 0000-0002-1226-3516
Giuseppe Di GiovanniDepartment of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.ORCID 0000-0003-2006-563X
University of Malta · MTCentre National de la Recherche Scientifique · FRUniversity of Bologna · ITUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsSerotonergic (5-HT) modulation of the lateral habenula (LHb) activity is central in normal and pathologic conditions such as mood disorders. Among the multiple 5-HT receptors (5-HTRs) involved, the 5-HT

methodsSingle-cell extracellular recording of the LHb neurons was used in rats to study the effect of the general activation and blockade of the 5-HT

resultsCumulative doses (5-640 μg/kg, iv) of Ro 60-0175 and TCB-2 affected the activity of 34% and 63% of the LHb recorded neurons, respectively. LHb neurons were either inhibited at low doses or excited at higher doses of the 5-HT

conclusionsPeripheral administration of 5-HT

Indexed as

Action PotentialsAnimalsDose-Response Relationship, DrugELAV-Like Protein 3Glutamate DecarboxylaseHabenulaMaleNerve Tissue ProteinsNeuronsPatch-Clamp TechniquesRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotonin AgentsElavl3 protein, ratELAV-Like Protein 3Glutamate Decarboxylaseglutamate decarboxylase 1Nerve Tissue ProteinsReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotonin Agentsaddictiondepressionimmunohistochemistrylateral habenulaserotonin

Identifiers

PMID29479825
PMCPMC6490100
OpenAlexW2790162006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.