Evidence map›Paper›PMID 29479795›Full record

ReviewTraffic (Copenhagen, Denmark)2018

The biology of extracellular microvesicles.

Alanna E Sedgwick, Crislyn D'Souza-Schorey

Open access · bronzeAbstract readReview
In one paragraph

Review in Traffic (Copenhagen, Denmark), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 238 citations in OpenAlex.

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  13. Crosstalk of extracellular vesicles in maternal-fetal interaction.Frontiers in cell and developmental biology · 2026
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alanna E SedgwickDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.
Crislyn D'Souza-SchoreyDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.ORCID 0000-0002-8389-055X
University of Notre Dame · US

Funding

Molecular Mechanisms of Cell InvasionR01CA115316 · NCI · UNIVERSITY OF NOTRE DAME · PI D'SOUZA-SCHOREY, CRISLYN · 2011 to 2016
$1.5M
NCI NIH HHS R01 CA115316
6 · The paper itself

Abstract

The study of extracellular vesicles (EVs) is a rapidly evolving field, owing in large part to recent advances in the realization of their significant contributions to normal physiology and disease. Once discredited as cell debris, these membrane vesicles have now emerged as mediators of intercellular communication by interaction with target cells, drug and gene delivery, and as potentially versatile platforms of clinical biomarkers as a result of their distinctive protein, nucleic acid and lipid cargoes. While there are multiple classes of EVs released from almost all cell types, here we focus primarily on the biogenesis, fate and functional cargoes of microvesicles (MVs). MVs regulate many important cellular processes including facilitating cell invasion, cell growth, evasion of immune response, stimulating angiogenesis, drug resistance and many others.

Indexed as

AnimalsBiological TransportExtracellular VesiclesHumansOrganelle Biogenesiscancercell invasionextracellular vesiclesmicrovesicles

Identifiers

PMID29479795
PMCPMC6922305
OpenAlexW2789857836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.