ArticleTransfusion2018
O- product transfusion, inventory management, and utilization during shortage: the OPTIMUS study.
Article in Transfusion, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue.Journal of clinical apheresis · 2026Guideline
- Improved allocation strategies for red cell units of blood group O and RhD-negative revealed by current suboptimal utilization.Journal of translational medicine · 2026Article
- Routine transfusion of Rh(D)-positive RBCs to Rh(D)-negative patients designated as do not resuscitate conserves Rh(D)-negative red blood cell inventory.Transfusion · 2026Article
- Revisiting whole blood transfusion for the massively bleeding patient: The origins of resistance to change.Transfusion · 2026Article
- ABO and RhD blood group antigen frequencies in patients and blood donors: Implications for the U.S. blood supply.PloS one · 2026Article
- Red blood cell inventory management: Insights from transfusion laboratory technologists in British Columbia, Canada.Transfusion medicine (Oxford, England) · 2025Article
- Estimating the risks of prehospital transfusion of D-positive whole blood to trauma patients who are bleeding in England.Vox sanguinis · 2022Article
- Multifaceted Benefit of Whole Blood Versus Lactated Ringer's Resuscitation After Traumatic Brain Injury and Hemorrhagic Shock in Mice.Neurocritical care · 2021Article
- Conservation of Rh negative Low Titer O Whole Blood (LTOWB) and the need for a national conversation to define its use in trauma transfusion protocols.Transfusion · 2021Article
- Anti-D immunization rates may exceed 50% in many clinically relevant settings, despite varying widely among patient cohorts.Transfusion · 2020Article
- Supplemental findings of the 2017 National Blood Collection and Utilization Survey.Transfusion · 2020Article
- A clinical audit on the utilization of group O-negative red cells and the lesson learnt.Asian journal of transfusion scienceArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite conservation strategies, shortages of O- red blood cells (RBCs) occur. The goal of this study was to determine how utilization of O- RBCs can be reduced using age- and location-based O+ substitution for routine transfusions in O- patients during O- shortages. STUDY DESIGN AND
methodsRecipient age and ABO and D group were obtained for allogeneic RBC transfusions during the 2016 calendar year from 31 participating centers. ABO and D group of each RBC unit was compared to that of the recipient to determine the number of O- RBC units transfused to all patients, the number of RBC units transfused to O- patients, and the number of O- RBC units transfused to O- patients. O- RBC transfusions to O- patients were further analyzed by patient age and location.
resultsThe fraction of all transfused RBCs that were O- at the participating centers ranged from 3.0% to 13.9%. The percentage of O- RBCs transfused to O- patients ranged from 36.6% to 93.7%. Hospitals differed in the frequency of issuing O- RBCs for O- patient transfusions (55.9%-100%). Relative to current issuing practice, overall use of O- RBCs could have been reduced by 44.5% if O+ units had been given to all O- patients at least 50 years old, 9.9% for all O- patients at least 80 years old, or 8.7% for all O- critical care patients at least 50 years old.
conclusionDuring O- shortages, O+ switching rules based on the recipient's age and hospital location can be applied for routine transfusions to ensure the availability of O- RBC units for O- females of childbearing age.
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