ReviewActa anaesthesiologica Scandinavica2018
Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure.
Review in Acta anaesthesiologica Scandinavica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19).Intensive care medicine · 2020Guideline
- Update of the recommendations of the Sociedade Portuguesa de Cuidados Intensivos and the Infection and Sepsis Group for the approach to COVID-19 in Intensive Care Medicine.Revista Brasileira de terapia intensivaPooled it
- A Comparison of Different Guidelines for the Treatment of Acute Heart Failure and Their Extensibility to Emergency Departments: A Critical Reappraisal.Journal of clinical medicine · 2025Review
- [Initial diagnosis and treatment of shock].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Association of Sequential Organ Failure Assessment (SOFA) components with mortality.Acta anaesthesiologica Scandinavica · 2022Article
- Medication and Fluid Management of Pediatric Sepsis and Septic Shock.Paediatric drugs · 2022Review
- [Pharmacological therapy of circulatory shock].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Article
- Characteristics, management and survival of ICU patients with coronavirus disease-19 in Norway, March-June 2020. A prospective observational study.Acta anaesthesiologica Scandinavica · 2021Observational
- [Individualized use of levosimendan in cardiac surgery].Der Anaesthesist · 2021Article
- [Perioperative pharmacological circulatory support in daily clinical routine].Der Anaesthesist · 2020Review
- Clinical, molecular, and epidemiological characterization of the SARS-CoV-2 virus and the Coronavirus Disease 2019 (COVID-19), a comprehensive literature review.Diagnostic microbiology and infectious disease · 2020Review
- Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).Critical care medicine · 2020Article
- Multidisciplinary Approach to the Diagnosis and In-Hospital Management of COVID-19 Infection: A Narrative Review.Frontiers in pharmacology · 2020Review
- Vasopressor therapy in critically ill patients with shock.Intensive care medicine · 2019Review
- Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure.Acta anaesthesiologica Scandinavica · 2018Review
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdult critically ill patients often suffer from acute circulatory failure and those with low cardiac output may be treated with inotropic agents. The aim of this Scandinavian Society of Anaesthesiology and Intensive Care Medicine guideline was to present patient-important treatment recommendations on this topic.
methodsThis guideline was developed according to GRADE. We assessed the following subpopulations of patients with shock: (1) shock in general, (2) septic shock, (3) cardiogenic shock, (4) hypovolemic shock, (5) shock after cardiac surgery, and (6) other types of shock, including vasodilatory shock. We assessed patient-important outcome measures, including mortality and serious adverse reactions.
resultsFor all patients, we suggest against the routine use of any inotropic agent, including dobutamine, as compared to placebo/no treatment (very low quality of evidence). For patients with shock in general, and in those with septic and other types of shock, we suggest using dobutamine rather than levosimendan or epinephrine (very low quality of evidence). For patients with cardiogenic shock and in those with shock after cardiac surgery, we suggest using dobutamine rather than milrinone (very low quality of evidence). For the other clinical questions, we refrained from giving any recommendations or suggestions.
conclusionsWe suggest against the routine use of any inotropic agent in adult patients with shock. If used, we suggest using dobutamine rather than other inotropic agents for the majority of patients, however, the quality of evidence was very low, implying high uncertainty on the balance between the benefits and harms of inotropic agents.
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