ArticleJournal of assisted reproduction and genetics2018
Correlation between the pronucleus size and the potential for human single pronucleus zygotes to develop into blastocysts : 1PN zygotes with large pronuclei can expect an embryo development to the blastocyst stage that is similar to the development of 2PN zygotes.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reconsidering the clinical value of 1PN-derived embryos: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- A large retrospective study on 1PN embryo transfer supports the need for updated harmonized best practice guidelines.Human reproduction (Oxford, England) · 2026Article
- The value of the pronucleus size of human single pronucleus zygotes as a predictor of fertility outcomes in conventional in vitro fertilization: a retrospective cohort study.European journal of medical research · 2026Article
- Time-series clustering of the migration speed of nucleolus-precursor bodies in human zygotes and live birth following assisted reproductive technology.Journal of assisted reproduction and genetics · 2025Article
- The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment†,‡.Human reproduction (Oxford, England) · 2025Article
- Incidence of haploidy and triploidy in trophectoderm biopsies of blastocysts derived from normally and abnormally fertilized oocytes.Journal of assisted reproduction and genetics · 2024Article
- Full-field optical coherence microscopy enables high-resolution label-free imaging of the dynamics of live mouse oocytes and early embryos.Communications biology · 2024Article
- Birth of Thirty-Two Healthy Babies Following Transfer of Fresh and Frozen-Thawed Embryos Derived from Monopronuclear Zygotes: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2024Article
- Migration speed of nucleolus precursor bodies in human male pronuclei: a novel parameter for predicting live birth.Journal of assisted reproduction and genetics · 2021Article
- Comparison of the rates for reaching the blastocyst stage between normal and abnormal pronucleus embryos monitored by a time-lapse system in IVF patientsJournal of the Turkish German Gynecological Association · 2021Article
- HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.Reproduction (Cambridge, England) · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this study, we examined the correlation between pronucleus size and the potential for human single pronucleus (1PN) zygotes to develop into blastocysts after IVF and ICSI.
methodsThis study included 112 patients who underwent a total of 112 cycles of IVF/ICSI. To evaluate embryo development, 1PN zygotes were compared with 2PN zygotes in the same IVF/ICSI cycle (control cycles) using time-lapse live embryo imaging. To assess the potential for blastocyst formation, cutoff values for pronuclear area and diameter were established through receiver operating characteristic curve analysis, after which 1PN zygotes were classified based on those cutoff values.
resultsAmong 1PN zygotes cultured to day 5/6, the rate of embryo development was significantly lower than from 2PN zygotes. However, the rates of blastocyst formation and good quality blastocysts from 1PN zygotes with large pronuclear areas (≥ 710 μm
conclusionsThe developmental potential of 1PN zygotes with large pronuclear areas (≥ 710 μm
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