Evidence map›Paper›PMID 29479561›Full record

ArticleACS biomaterials science & engineering2017

Using biomimetic polymers in place of noncollagenous proteins to achieve functional remineralization of dentin tissues.

Yung-Ching Chien, Jinhui Tao, Kuniko Saeki, Alexander F Chin, Jolene L Lau, Chun-Long Chen, Ronald N Zuckermann, Sally J Marshall, Grayson W Marshall, James J De Yoreo

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Amyloid-like amelogenin nanoribbons template mineralization via a low-energy interface of ion binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Biomineralization of Collagen-Based Materials for Hard Tissue Repair.International journal of molecular sciences · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yung-Ching ChienMolecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720.
Jinhui TaoMolecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720.
Kuniko SaekiDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, CA, 94143.
Alexander F ChinDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, CA, 94143.
Jolene L LauMolecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720.
Chun-Long ChenMolecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720.
Ronald N ZuckermannMolecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720.
Sally J MarshallDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, CA, 94143.
Grayson W MarshallDepartment of Preventive and Restorative Dental Sciences, University of California, San Francisco, CA, 94143.
James J De YoreoMolecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720.
University of California, San Francisco · USLawrence Berkeley National Laboratory · USPacific Northwest National Laboratory · US

Funding

DENTIN STRUCTURE, DEMINERALIZATION AND REMINERALIZATIONR01DE016849 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOWER, LAURIE B, HABELITZ, STEFAN FRIEDRICH · 2006 to 2016
$5.1M
NIDCR NIH HHS R01 DE016849
6 · The paper itself

Abstract

In calcified tissues such as bones and teeth, mineralization is regulated by an extracellular matrix, which includes non-collagenous proteins (NCP). This natural process has been adapted or mimicked to restore tissues following physical damage or demineralization by using polyanionic acids in place of NCPs, but the remineralized tissues fail to fully recover their mechanical properties. Here we show that pre-treatment with certain amphiphilic peptoids, a class of peptide-like polymers consisting of N-substituted glycines that have defined monomer sequences, enhances ordering and mineralization of collagen and induces functional remineralization of dentin lesions

Indexed as

dentin remineralizationin-situ AFMNanoindentationPeptoidsSEMTEM

Identifiers

PMID29479561
PMCPMC5821432
OpenAlexW2767037605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.