Evidence map›Paper›PMID 29479550›Full record

ArticleOpen forum infectious diseases2018

Sexually Transmitted Infections Among HIV-Infected Individuals in the District of Columbia and Estimated HIV Transmission Risk: Data From the DC Cohort.

Jose Lucar, Rachel Hart, Nabil Rayeed, Arpi Terzian, Amy Weintrob, Marc Siegel, David M Parenti, Leah E Squires, Rush Williams, Amanda D Castel and 2 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Jose LucarDivision of Infectious Diseases, The George Washington University Medical Center, Washington, DC.
Rachel HartCerner Corporation, Kansas City, Missouri.
Nabil RayeedCerner Corporation, Kansas City, Missouri.
Arpi TerzianMilken School of Public Health.
Amy WeintrobDivision of Infectious Diseases, The George Washington University Medical Center, Washington, DC.
Marc SiegelDivision of Infectious Diseases, The George Washington University Medical Center, Washington, DC.
David M ParentiDivision of Infectious Diseases, The George Washington University Medical Center, Washington, DC.
Leah E SquiresInfectious Diseases Section, Veterans Affairs Medical Center, Washington, DC.
Rush WilliamsInfectious Diseases Section, Veterans Affairs Medical Center, Washington, DC.
Amanda D CastelMilken School of Public Health.
Debra A BenatorDivision of Infectious Diseases, The George Washington University Medical Center, Washington, DC.
DC Cohort Executive Committee
George Washington University · USCerner (United States) · USMilken Institute · USVeterans Health Administration · USWashington University Medical Center · USColumbia University · US

Funding

The DC Cohort: A Longitudinal Population-Based Cohort Study of People Living with HIV in Washington, DCR24AI152598 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Amanda Derryck Castel, Marinella Temprosa · 2020 to 2026
$37.9M
CPCRA Clinical Trials UnitU01AI069503 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI GORDIN, FRED M · 2007 to 2011
$33.9M
DC Partnership for HIV/AIDS Progress (DC PFAP)ZIACL009010 · CLC · CLINICAL CENTER · PI MASUR, HENRY · 2010 to 2025
$0k
NIAID NIH HHS R24 AI152598NIAID NIH HHS U01 AI069503
6 · The paper itself

Abstract

backgroundWashington, DC, has one of the highest rates of HIV infection in the United States. Sexual intercourse is the leading mode of HIV transmission, and sexually transmitted infections (STIs) are a risk factor for HIV acquisition and transmission.

methodsWe evaluated the incidence and demographic factors associated with chlamydia, gonorrhea, and syphilis among HIV-infected persons enrolled at 13 DC Cohort sites from 2011 to 2015. Using Poisson regression, we assessed covariates of risk for incident STIs. We also examined HIV viral loads (VLs) at the time of STI diagnosis as a proxy for HIV transmission risk.

resultsSix point seven percent (451/6672) developed an incident STI during a median follow-up of 32.5 months (4% chlamydia, 3% gonorrhea, 2% syphilis); 30% of participants had 2 or more STI episodes. The incidence rate of any STIs was 3.8 cases per 100 person-years (95% confidence interval [CI], 3.5-4.1); age 18-34 years, 10.8 (95% CI, 9.7-12.0); transgender women, 9.9 (95% CI, 6.9-14.0); Hispanics, 9.2 (95% CI, 7.2-11.8); and men who have sex with men (MSM), 7.7 (95% CI, 7.1-8.4). Multivariate Poisson regression showed younger age, Hispanic ethnicity, MSM risk, and higher nadir CD4 counts to be strongly associated with STIs. Among those with an STI, 41.8% had a detectable VL within 1 month of STI diagnosis, and 14.6% had a VL ≥1500 copies/mL.

conclusionsSTIs are highly prevalent among HIV-infected persons receiving care in DC. HIV transmission risk is considerable at the time of STI diagnosis. Interventions toward risk reduction, antiretroviral therapy adherence, and HIV virologic suppression are critical at the time of STI evaluation.

Indexed as

District of ColumbiaHIVhuman immunodeficiency virussexually transmitted infectionsSTI

Identifiers

PMID29479550
PMCPMC5804762
OpenAlexW2791449832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.