ArticleInternational journal of retina and vitreous2018
Inverted ILM flap, free ILM flap and conventional ILM peeling for large macular holes.
Article in International journal of retina and vitreous, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Critical analysis of macular hole repair techniques: a comprehensive systematic review and meta-analysis comparing internal limiting membrane flap and internal limiting membrane peeling for any size of macular hole.BMC ophthalmology · 2025Pooled it
- Inverted Internal Limiting Membrane Flap Technique versus Internal Limiting Membrane Peeling for Large Macular Holes: A Meta-Analysis of Randomized Controlled Trials.Ophthalmic research · 2021Pooled it
- Comparative efficacy evaluation of inverted internal limiting membrane flap technique and internal limiting membrane peeling in large macular holes: a systematic review and meta-analysis.BMC ophthalmology · 2020Pooled it
- Pooled it
- Comparative study of inverted internal limiting membrane (ILM) flap and ILM peeling technique in large macular holes: a randomized-control trial.BMC ophthalmology · 2018Trial
- Modification of the Temporal Inverted Internal Limiting Membrane Flap in Macular Hole Surgery: Envelope TechniqueTurkish journal of ophthalmology · 2026Article
- Comparison of ILM peeling vs. inverted ILM flap for macular hole closure and visual outcomes: systematic review and meta-analysis.International journal of retina and vitreous · 2025Review
- Predicting anatomical success and retinal restoration following macular hole surgery using optical coherence tomography parameters.BMC ophthalmology · 2025Article
- Classification and management of myopic traction maculopathy: a vitrectomy-based consensus from taiwanese experts.International ophthalmology · 2025Article
- Development of a prognostic surgical index using optical coherence tomography for large macular holes: a retrospective multicenter study.BMC ophthalmology · 2025Article
- Article
- Modified ILM flap techniques versus classical inverted ILM flap technique for large macular holes: a systematic review and meta-analysis of randomized controlled trials.International journal of retina and vitreous · 2024Article
- Comparison of the use of internal limiting membrane flaps versus conventional ILM peeling on post-operative anatomical and visual outcomes in large macular holes.Eye (London, England) · 2024Article
- Successful closure of a refractory giant (15 sq mm) macular hole with amniotic membrane graft.Journal of surgical case reports · 2024Article
- Anatomical and functional results after vitrectomy with conventional ILM peeling versus inverted ILM flap technique in large full-thickness macular holes.International journal of retina and vitreous · 2023Article
- Pars plana vitrectomy with internal limiting membrane flap versus pars plana vitrectomy with conventional internal limiting membrane peeling for large macular hole.The Cochrane database of systematic reviews · 2023Review
- Comparison of anatomical and functional outcomes of different surgical techniques in myopic macular hole without retinal detachment.International journal of ophthalmology · 2023Article
- Short-Term Clinical Results After ILM Removal and Inverted ILM Flap for Macular Hole Repair - A Single-Center Retrospective Experience.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Comparison of three techniques of harvesting full-thickness retinal tissue for large or persistent macular holes.Indian journal of ophthalmology · 2022Article
- Postoperative microstructural re-modelling and functional outcomes in idiopathic full thickness macular hole.Indian journal of ophthalmology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess closure rate after a single surgery of large macular holes and their visual recovery in the short term with three different surgical techniques.
methodsProspective multicenter randomized controlled trial. We included treatment-naïve patients with diagnosis of large macular hole (minimum diameter of > 400 µm). All patients underwent a comprehensive ophthalmological examination. Before surgery, the patients were randomized into three groups: group A: conventional internal limiting membrane peeling, group B: inverted-flap technique and group C: free-flap technique. All study measurements were repeated within the period of 1 and 3 months after surgery. Continuous variables were assessed with a Kruskal-Wallis test, change in visual acuity was assessed with analysis of variance for repeated measurements with a Bonferroni correction for statistical significance.
resultsThirty-eight patients were enrolled (group A: 12, group B: 12, group C: 14). The closure rate was in group A and B: 91.6%; 95% CI 61.52-99.79%. In group C: 85.71%; 95% CI 57.19-98.22%. There were no differences in the macular hole closure rate between groups (
conclusionsDespite all techniques displayed a trend toward visual improvement, the inverted-flap technique seems to induce a faster and more significant recovery in the short term.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.