Evidence map›Paper›PMID 29479369›Full record

ArticleFrontiers in genetics2018

The Circular RNA Profiles of Colorectal Tumor Metastatic Cells.

Weiqin Jiang, Xingchen Zhang, Qinjie Chu, Sen Lu, Linfu Zhou, Xingang Lu, Chen Liu, Lingfeng Mao, Chuyu Ye, Michael P Timko and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  7. Oncology letters · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Circular RNA in colorectal cancer.Journal of cellular and molecular medicine · 2021
    Review
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Weiqin JiangCancer Biotherapy Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xingchen ZhangDepartment of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China.
Qinjie ChuDepartment of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China.
Sen LuDepartments of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Linfu ZhouMedical Biotechnology Laboratory, Zhejiang University, Hangzhou, China.
Xingang LuThe 2nd Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, China.
Chen LiuDepartment of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China.
Lingfeng MaoDepartment of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China.
Chuyu YeDepartment of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China.
Michael P TimkoDepartments of Biology and Public Health Science, University of Virginia, Charlottesville, VA, United States.
Longjiang FanDepartment of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China.
Haixing JuZhejiang Cancer Hospital, Hangzhou, China.
Zhejiang University · CNZhejiang Cancer Hospital · CNFirst Affiliated Hospital Zhejiang University · CNHangzhou Center for Disease Control and Prevention · CNUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) have been reported that can be used as biomarkers for colorectal cancers (CRC) and other types of tumors. However, a limited number of studies have been performed investigating the potential role of circRNAs in tumor metastasis. Here, we examined the circRNAs in two CRC cell lines (a primary tumor cell SW480 and its metastasis cell SW620), and found a large set of circRNA (2,919 ncDECs) with significantly differential expression patterns relative to normal cells (NCM460). In addition, we uncovered a set of 623 pmDECs that differ between the primary CRC cells and its metastasis cells. Both differentially expressed circRNA (DEC) sets contain many previously unknown putative CRC-related circRNAs, thereby providing many new circRNAs as candidate biomarkers for CRC development and metastasis. These studies are the first large-scale identification of metastasis-related circRNAs for CRC and provide valuable candidate biomarkers for diagnostic and a starting point for additional investigations of CRC metastasis.

Indexed as

Circular RNA (circRNA)colorectal cancer (CRC)differential expressed circRNA (DEC)metastasisSW480 and SW620 cell line

Identifiers

PMID29479369
PMCPMC5811837
OpenAlexW2789234629

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.