Evidence map›Paper›PMID 29479231›Full record

ArticlePaediatrics & child health2017

Initiation of passive cooling at referring centre is most predictive of achieving early therapeutic hypothermia in asphyxiated newborns.

Brigitte Lemyre, Linh Ly, Vann Chau, Anil Chacko, Nicholas Barrowman, Hilary Whyte, Steven P Miller

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatrics & child health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Observational
  5. Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy.Current neurology and neuroscience reports · 2019
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Brigitte LemyreDepartment of Pediatrics, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario.
Linh LyDepartment of Pediatrics (Neonatology), The Hospital for Sick Children and University of Toronto, Toronto, Ontario.
Vann ChauDepartment of Pediatrics (Neurology), The Hospital for Sick Children and University of Toronto, Toronto, Ontario.
Anil ChackoDepartment of Pediatrics (Neonatology), The Hospital for Sick Children and University of Toronto, Toronto, Ontario.
Nicholas BarrowmanChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario.
Hilary WhyteDepartment of Pediatrics (Neonatology), The Hospital for Sick Children and University of Toronto, Toronto, Ontario.
Steven P MillerDepartment of Pediatrics (Neurology), The Hospital for Sick Children and University of Toronto, Toronto, Ontario.
SickKids Foundation · CAChildren's Hospital of Eastern Ontario · CAHospital for Sick Children · CAMental Health Research Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify factors associated with early initiation and achievement of therapeutic hypothermia (TH) in newborns with hypoxic-ischemic encephalopathy (HIE).

methodsRetrospective cohort study of newborns who received TH according to National Institute of Child Health and Human Development (NICHD) criteria in two academic level 3 Neonatal Intensive Care Units (NICU) between 2009 and 2013. All infants were transported by a neonatal transport team (NNTT). Multivariate linear regression including who initiated cooling and degree of resuscitation in the model was performed.

resultsTwo hundred and seven infants were included. Waiting for advice from a tertiary care NICU was independently associated with a 50 minute delay in the median time of initiation of TH. The need for extensive resuscitation (cardiopulmonary resuscitation [CPR] or epinephrine) was independently associated with a reduction of 43 minutes in the median time to reach target core temperature. Log-transformed time to initiation of TH was associated with time to reach target core temperature (P<0.001). A doubling of time to initiation of TH corresponds to a 24% (95% CI 18% to 30%) increase in median time to reach target core temperature.

conclusionsInitiating passive cooling at the referring centre, before transfer, is critical to faster achievement of target core temperature in asphyxiated infants. Greater outreach education and development of clinical care pathways are needed to improve optimal delivery of TH to enhance outcome.

Indexed as

AsphyxiaHypothermiaNewborn.

Identifiers

PMID29479231
PMCPMC5804879
OpenAlexW2617131452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.