ArticlePaediatrics & child health2017
Efficacy of minimally invasive surfactant therapy in moderate and late preterm infants: A multicentre randomized control trial.
Article in Paediatrics & child health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Safety of Less Invasive Surfactant Administration in Preterm Infants: A Meta-Analysis.Pediatric pulmonology · 2026Pooled it
- Comparative efficacy and safety of pulmonary surfactant delivery strategies in neonatal RDS: a network meta-analysis.BMC pulmonary medicine · 2024Pooled it
- Sedation for less invasive surfactant administration in preterm infants: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- Surfactant delivery via thin catheter in preterm infants: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2021Pooled it
- Original research: surfactant administration using less invasive surfactant administration (LISA) versus enhanced intubate-surfactant-extubate (ENSURE) in preterm infants.European journal of pediatrics · 2026Trial
- Vibrating mesh nebulizers vs. less invasive surfactant administration in the treatment of preterm respiratory distress syndrome: a multicenter, open-label, exploratory, randomized clinical trial.European journal of medical research · 2025Trial
- Comparing the Effects of Two Surfactant Administration Methods: Minimally Invasive Surfactant Therapy (MIST) with Intubation (INSURE) in Infants with Respiratory Distress Syndrome.Advances in respiratory medicine · 2024Trial
- Effects of a respiratory care protocol incorporating less invasive surfactant administration in infants born at 30-34 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Surfactant administration in late preterm and term neonates: is LISA ready for routine use?European journal of pediatrics · 2026Review
- Minimally invasive surfactant therapy outcomes in infants born at 28-37 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Non-Invasive Surfactant Administration in Preterm Infants.Children (Basel, Switzerland) · 2026Review
- Effectiveness of A Respiratory Care Protocol Including Less Invasive Surfactant Administration in ≥ 35 Weeks Gestational Age Infants.Pediatric pulmonology · 2025Article
- Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis.EClinicalMedicine · 2023Article
- Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies.Antioxidants (Basel, Switzerland) · 2023Review
- Should less invasive surfactant administration (LISA) become routine practice in US neonatal units?Pediatric research · 2023Review
- Less Invasive Surfactant Administration: A Review of Current Evidence of Clinical Outcomes With Beractant.Cureus · 2022Review
- Early surfactant and non-invasive ventilation versus intubation and surfactant: a propensity score-matched national study.BMJ paediatrics open · 2022Article
- Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial.Clinical and experimental pediatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMinimally invasive surfactant therapy (MIST) is a new strategy to avoid mechanical ventilation (MV) in respiratory distress syndrome. The primary aim of this study was to test MIST as a means of avoiding MV exposure and pneumothorax occurrence in moderate and late preterm infants (32 to 36 weeks' gestational age).
methodsThis was a randomized controlled trial including three Canadian centres. Patients were randomized to standard management or to the intervention if they required nasal continuous positive airway pressure of 6 cm H
resultsAmong 45 randomized patients, 24 were assigned to MIST and 21 to standard management. Eight infants (33%) from the intervention group met the primary outcome criteria versus 19 (90%) in the control group (absolute risk reduction 0.57, 95% confidence interval 0.54 to 0.60). One patient in each group reached the primary outcome because of pneumothorax occurrence. The other patients were exposed to MV. None of the patients reached the clinical failure criteria.
conclusionMIST for respiratory distress syndrome management in moderate and late preterm infants was associated with a significant reduction of MV exposure and pneumothorax occurrence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.