ArticleJournal of toxicologic pathology2018
Size-dependent acute toxicity of silver nanoparticles in mice.
Article in Journal of toxicologic pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Anti-inflammatory activity of Silver Nanoparticles (AgNPs): An Updated Systematic review from in vivo, and in vitro studies.Inflammopharmacology · 2026Pooled it
- The Effect of Silver Nanoparticle Addition on the Antimicrobial Properties of Poly(methyl methacrylate) Used for Fabrication of Dental Appliances: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Restorative potential of laser-synthesized silver nanoparticles withBeilstein journal of nanotechnology · 2026Article
- Silver Nanoparticles (AgNPs) as Potential Antiviral Agents: Synthesis, Biophysical Properties, Safety, Challenges and Future Directions─Update Review.Molecules (Basel, Switzerland) · 2025Review
- Silver Nanoparticles Help Plants Grow, Alleviate Stresses, and Fight Against Pathogens.Plants (Basel, Switzerland) · 2025Review
- Flavonoid-mediated biofilm inhibition and toxicological evaluation ofFrontiers in pharmacology · 2025Article
- Effects of silver nanoparticles on the physiology, stress, and mineral uptake of banana cultivarsFrontiers in plant science · 2025Article
- Green Synthesis of Silver Nanoparticles with Roasted Green Tea: Applications in Alginate-Gelatin Hydrogels for Bone Regeneration.Gels (Basel, Switzerland) · 2024Article
- Silver Nanoparticles: A Comprehensive Review of Synthesis Methods and Chemical and Physical Properties.Nanomaterials (Basel, Switzerland) · 2024Review
- Efficacy of silver nanoparticles against Trichinella spiralis in mice and the role of multivitamin in alleviating its toxicity.Scientific reports · 2024Article
- Toxicity Assessment of New Ag-ZnO/AgO Nanocomposites: An In Vitro and In Vivo Approach.Journal of functional biomaterials · 2024Article
- Metal-Based Nanoparticles for Cardiovascular Diseases.International journal of molecular sciences · 2024Review
- Recent advances in nanoantibiotics against multidrug-resistant bacteria.Nanoscale advances · 2023Review
- Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice.Archives of toxicology · 2023Article
- Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy.Cells · 2023Review
- Biosynthesized Nanosilver from Ginger Extract Exhibits Antioxidant and Hepatic Responses duringACS omega · 2023Article
- Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in rats.Particle and fibre toxicology · 2023Article
- Size Analysis of Silver and Gold Nanoparticles Using Laser Ablation Single Particle ICP Mass Spectrometry: Evaluation of the Laser-Induced Disintegration of Nanoparticles.Mass spectrometry (Tokyo, Japan) · 2023Article
- Development of New Health Risk Assessment of Nanoparticles: EPA Health Risk Assessment Revised.Nanomaterials (Basel, Switzerland) · 2022Article
- Anti-liver fibrosis activity of curcumin/chitosan-coated green silver nanoparticles.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we aimed to evaluate changes in the acute toxicity of intraperitoneally administered silver nanoparticles (AgNPs) of varying sizes in BALB/c mice. Seven-week-old female BALB/c mice were intraperitoneally administered AgNPs measuring 10, 60, or 100 nm in diameter (0.2 mg/mouse) and then sacrificed 1, 3, or 6 h after treatment. In mice administered 10 nm AgNPs, reduced activity and piloerection were observed at 5 h post administration, and lowered body temperature was observed at 6 h post administration, with histopathological changes of congestion, vacuolation, single cell necrosis, and focal necrosis in the liver; congestion in the spleen; and apoptosis in the thymus cortex. These histopathological changes were not evident following administration of either 60 or 100 nm AgNPs. These results suggested that smaller AgNPs, e.g., those measuring 10 nm in diameter, had higher acute toxicity in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.