ArticleCurrent biology : CB2018
Feeding-State-Dependent Modulation of Temperature Preference Requires Insulin Signaling in Drosophila Warm-Sensing Neurons.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- The neuronal circuits and cellular encoding of thermosensation.Nature reviews. Neuroscience · 2026Review
- THERM-D Uncovers Distinct Neural Mechanisms Separating Morning and Evening Body Temperature Rhythms inbioRxiv : the preprint server for biology · 2026Article
- Effect of a Combined Antidepressant Drug Flupentixol-Melitracen on Glucose Level and Expression of Insulin-Like Peptide Genes DILP5 and DILP6 in Drosophila melanogaster.BioMed research international · 2026Article
- Article
- A brain-derived insulin signal encodes protein satiety for nutrient-specific feeding inhibition.Cell reports · 2024Article
- Reinstated Activity of Human Tau-induced Enhanced Insulin Signaling Restricts Disease Pathogenesis by Regulating the Functioning of Kinases/Phosphatases and Tau Hyperphosphorylation in Drosophila.Molecular neurobiology · 2024Article
- Functional relationship between peripheral thermosensation and behavioral thermoregulation.Frontiers in neural circuits · 2024Review
- Review
- Independent insulin signaling modulators govern hot avoidance under different feeding states.PLoS biology · 2023Article
- Molecular and Neural Mechanisms of Temperature Preference Rhythm inJournal of biological rhythms · 2023Review
- Review
- Life history strategy dictates thermal preferences across the diel cycle and in response to starvation in variable field crickets,Current research in insect science · 2022Article
- Internal State: Dynamic, Interconnected Communication Loops Distributed Across Body, Brain, and Time.Integrative and comparative biology · 2021Article
- Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (International journal of molecular sciences · 2021Article
- DIlp7-Producing Neurons Regulate Insulin-Producing Cells inFrontiers in physiology · 2021Article
- Neural Circuits Underlying Behavioral Flexibility: Insights FromFrontiers in behavioral neuroscience · 2021Review
- Functional expression of Δ12 fatty acid desaturase modulates thermoregulatory behaviour in Drosophila.Scientific reports · 2020Article
- Insulin and 20-hydroxyecdysone oppose each other in the regulation of phosphoinositide-dependent kinase-1 expression during insect pupation.The Journal of biological chemistry · 2018Article
- Article
- Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vectorProceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Starvation is life-threatening and therefore strongly modulates many aspects of animal behavior and physiology [1]. In mammals, hunger causes a reduction in body temperature and metabolism [2], resulting in conservation of energy for survival. However, the molecular basis of the modulation of thermoregulation by starvation remains largely unclear. Whereas mammals control their body temperature internally, small ectotherms, such as Drosophila, set their body temperature by selecting an ideal environmental temperature through temperature preference behaviors [3, 4]. Here, we demonstrate in Drosophila that starvation results in a lower preferred temperature, which parallels the reduction in body temperature in mammals. The insulin/insulin-like growth factor (IGF) signaling (IIS) pathway is involved in starvation-induced behaviors and physiology and is well conserved in vertebrates and invertebrates [5-7]. We show that insulin-like peptide 6 (Ilp6) in the fat body (fly liver and adipose tissues) is responsible for the starvation-induced reduction in preferred temperature (T
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.