ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2018
Sequential drain amylase to guide drain removal following pancreatectomy.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Optimizing drain management following distal pancreatectomy: fewer drains and earlier removal guided by drain fluid amylase and C-reactive protein levels.Surgical endoscopy · 2026Article
- Postoperative day 3 biomarkers for risk stratification and prediction of clinically relevant pancreatic fistula after pancreaticoduodenectomy: A retrospective cohort study.Surgery in practice and science · 2026Article
- Optimal cutoff values of drain amylase for predicting pancreatic fistula are different between open and laparoscopic distal pancreatectomy.Surgical endoscopy · 2024Article
- Evaluation and Recalibration of Risk-Stratified Pancreatoduodenectomy Drain Fluid Amylase Removal Criteria.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Innovations in pancreatic anastomosis technique during pancreatoduodenectomies.Langenbeck's archives of surgery · 2020Article
- Prospective study on predictability of complications by pancreatic surgeons.Langenbeck's archives of surgery · 2020Observational
- Article
- Evolving the Paradigm of Early Drain Removal Following Pancreatoduodenectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlthough used as criterion for early drain removal, postoperative day (POD) 1 drain fluid amylase (DFA) ≤ 5000 U/L has low negative predictive value for clinically relevant postoperative pancreatic fistula (CR-POPF). It was hypothesized that POD3 DFA ≤ 350 could provide further information to guide early drain removal.
methodsData from a pancreas surgery consortium database for pancreatoduodenectomy and distal pancreatectomy patients were analyzed retrospectively. Those patients without drains or POD 1 and 3 DFA data were excluded. Patients with POD1 DFA ≤ 5000 were divided into groups based on POD3 DFA: Group A (≤350) and Group B (>350). Operative characteristics and 60-day outcomes were compared using chi-square test.
resultsAmong 687 patients in the database, all data were available for 380. Fifty-five (14.5%) had a POD1 DFA > 5000. Among 325 with POD1 DFA ≤ 5000, 254 (78.2%) were in Group A and 71 (21.8%) in Group B. Complications (35 (49.3%) vs 87 (34.4%); p = 0.021) and CR-POPF (13 (18.3%) vs 10 (3.9%); p < 0.001) were more frequent in Group B.
conclusionsIn patients with POD1 DFA ≤ 5000, POD3 DFA ≤ 350 may be a practical test to guide safe early drain removal. Further prospective testing may be useful.
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