Evidence map›Paper›PMID 29478256›Full record

Trial reportClinical transplantation2018

Impact of early reoperation on graft survival after liver transplantation: Univariate and multivariate analysis.

Ahmed M Elsabbagh, Raffaele Girlanda, Jason Hawksworth, Matthew D Pichert, Cassie Williams, Agostino Pozzi, Alexander Kroemer, Anupama Nookala, Coleman Smith, Cal S Matsumoto and 1 more

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Clinical transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Ahmed M ElsabbaghMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.ORCID 0000-0003-4773-8144
Raffaele GirlandaMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Jason HawksworthMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Matthew D PichertMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Cassie WilliamsMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Agostino PozziMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Alexander KroemerMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Anupama NookalaMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Coleman SmithMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Cal S MatsumotoMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Thomas M FishbeinMedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC, USA.
Georgetown University · USMansoura University · EG

Funding

Protective and Proinflammatory Immunological Mechanisms behind Liver Ischemia Reperfusion Injury in Marginal LiversR21AI130800 · NIAID · GEORGETOWN UNIVERSITY · PI KROEMER, ALEXANDER HELMUT KURT · 2018 to 2019
$449k
NIAID NIH HHS R21 AI130800
6 · The paper itself

Abstract

backgroundData on rate, risk factors, and consequences of early reoperation after liver transplantation are still limited. STUDY

designSingle-center retrospective analysis of data of 428 patients, who underwent liver transplantation in period between January 2009 and December 2014. Univariate and multivariate analysis were used to study the risk factors of early reoperation and its impact on graft survival.

resultsOf 428 patients, 74 (17.3%) underwent early reoperation. Of them, 46 (62.2%) underwent reoperation within the first week and 28 (37.8%) underwent reoperation later than 1 week after transplantation. With multivariate analysis, significant risk factors of early reoperation included pretransplant ICU admission, previous abdominal surgery and diabetes. Early reoperation itself was not found to be an independent predictor of graft loss. However, early reoperation later than 7 days from transplant was found to be independent predictor of graft loss (odds ratio [OR] = 5.125; 95% CI, 1.358-19.552; P = .016). In our series, other independent predictors of graft loss were MELD score (P = .010) and operative time (P = .048).

conclusionsThis analysis demonstrates that early reoperations later than a week appear to negatively impact the graft survival. The timing of early reoperation should be a focus of additional studies.

Indexed as

Graft SurvivalPostoperative ComplicationsReoperationAdolescentAdultAgedEnd Stage Liver DiseaseFemaleFollow-Up StudiesHumansLiver TransplantationMaleMiddle AgedPrognosisRetrospective StudiesTime-to-Treatmentearly reoperationgraft survivalliver transplantation

Identifiers

PMID29478256
PMCPMC6433119
OpenAlexW2792795379

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.