Evidence map›Paper›PMID 29478192›Full record

ArticleDysphagia2018

Neural Mechanisms of Swallowing Dysfunction and Apraxia of Speech in Acute Stroke.

Lydia A Trupe, Rachel W Mulheren, Donna Tippett, Argye E Hillis, Marlís González-Fernández

Open access · greenAbstract read
In one paragraph

Article in Dysphagia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Clinical outcomes associated with speech, language and swallowing difficulties post-stroke.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2023
    Article
  6. Swallowing Apraxia Post Ischemic Stroke.International journal of environmental research and public health · 2022
    Article
  7. Article
  8. Article
  9. A Case of Crossed Apraxia for Propositional Speech.Annals of Indian Academy of Neurology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lydia A TrupeDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Rachel W MulherenDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Donna TippettDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Argye E HillisDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Marlís González-FernándezDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA. mgonzal5@jhmi.edu.ORCID 0000-0002-1576-3452
Johns Hopkins University · US

Funding

Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Neural Basis of Coexisting Swallowing and Communication Disorders after StrokeK23DC011056 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI GONZALEZ-FERNANDEZ, MARLIS · 2013 to 2017
$1.2M
TO CONDUCT AND ADMINISTER SCIENTIFIC REVIEW BY CRDCU09DC001156 · NIDCD · UTAH STATE UNIVERSITY · PI OBERHOLTZER, JOHN CARL · 1990 to 2004
$1.1M
NIDCD NIH HHS K23 DC011056NIDCD NIH HHS K23DC01156NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01DC05375NIDCD NIH HHS U09 DC001156
6 · The paper itself

Abstract

Speech and swallowing utilize overlapping anatomy and are thus inherently related processes. We sought to identify common neural mechanisms between risk of swallowing dysfunction and apraxia of speech (AOS). This was a retrospective analysis using data from a prospectively collected cohort. Left hemisphere stroke patients (68 subjects) tested with the Apraxia Battery for Adults II, a swallow screen, and MRI were included in the study. Main outcome measure was the presence of AOS or aspiration risk after stroke. We identified a significant association between AOS measures and increased aspiration risk (defined by failed swallow screen; p = 0.04; OR 5.2). Lesions in pars opercularis of Broca's area (BA 44) were associated with both AOS (p = 0.044; OR 9.7) and increased aspiration risk (p = 0.04; OR 5) but deficits rarely co-occurred in the same cases. Lesions in left premotor cortex (BA 6) were not significantly associated with increased aspiration risk (p = 0.06; OR 3.3) but were significantly associated with AOS (p = 0.008; OR 7). Impaired swallowing function was also associated with lesions in Wernicke's area (BA 22; p = 0.05; OR 3.5) and pars triangularis (BA 45; p = 0.02; OR 6.8). AOS and risk of aspiration are associated in patients with acute left hemisphere stroke. Acute infarct in the pars opercularis of Broca's area is associated with both deficits, though they rarely co-occur in the same individual. The co-occurrence of AOS and risk of aspiration likely reflects dependence on closely related neural structures.

Indexed as

ApraxiasDeglutitionDeglutition DisordersFemaleHumansMaleMiddle AgedPilot ProjectsProspective StudiesRetrospective StudiesSpeechStrokeApraxia of speechAspirationBroca’s areaDeglutitionDeglutition disordersDysphagiaStrokeSwallowing

Identifiers

PMID29478192
PMCPMC6510585
OpenAlexW2788423609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.