Evidence map›Paper›PMID 29478187›Full record

Trial reportEuropean journal of nutrition2019

Efficacy and safety of American ginseng (Panax quinquefolius L.) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: a double-blind, randomized, cross-over clinical trial.

Vladimir Vuksan, Zenith Zheng Xu, Elena Jovanovski, Alexandra L Jenkins, Uljana Beljan-Zdravkovic, John L Sievenpiper, P Mark Stavro, Andreea Zurbau, Lea Duvnjak, Michael Z C Li

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02923453 (Efficacy and Safety of American Ginseng), which is not on this map. Cited by 37 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 5 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02923453 phase2completednot on this map

Efficacy and Safety of American Ginseng (Penax Quinquefolius) Extract on Glycemic Control in Individuals With Type 2 Diabetes: A Double-blind, Randomized, Crossover Clinical Trial

TypeinterventionalSponsorUnity Health TorontoRan1998 to 2002Enrolled23ConditionsType II Diabetes ControlArmsCNT 2000 American ginseng extract, Placebo
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
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  10. Improving glucose tolerance in obese rats: the role of Jinlida granules ( ) in gut microbiota modulation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
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  15. Effects of saponins RbFrontiers in molecular biosciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Vladimir VuksanClinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada. v.vuksan@utoronto.ca.ORCID http://orcid.org/0000-0001-8541-4058
Zenith Zheng XuClinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.
Elena JovanovskiClinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.
Alexandra L JenkinsClinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.
Uljana Beljan-ZdravkovicClinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.
John L SievenpiperClinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.
P Mark StavroClinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.
Andreea ZurbauClinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON, Canada.
Lea DuvnjakVuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases-UH Merkur, School of Medicine, University of Zagreb, Zagreb, Croatia.
Michael Z C LiChai-Na-Ta Corp., Langley, BC, Canada.
St. Michael's Hospital · CAChai-Na-Ta (Canada) · CAUniversity of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDespite the lack of evidence, a growing number of people are using herbal medicine to attenuate the burden of diabetes. There is an urgent need to investigate the clinical potential of herbs. Preliminary observations suggest that American ginseng (Panax quinquefolius [AG]) may reduce postprandial glycemia. Thus, we aimed to evaluate the efficacy and safety of AG as an add-on therapy in individuals with type 2 diabetes (T2DM) controlled by conventional treatment.

methods24 individuals living with T2DM completed the study (F:M = 11:13; age = 64 ± 7 year; BMI = 27.8 ± 4.6 kg/m

resultsCompared to placebo, AG significantly reduced HbA1c (- 0.29%; p = 0.041) and fasting blood glucose (- 0.71 mmol/L; p = 0.008). Furthermore, AG lowered systolic blood pressure (- 5.6 ± 2.7 mmHg; p < 0.001), increased NOx (+ 1.85 ± 2.13 µmol/L; p < 0.03), and produced a mean percent end-difference of - 12.3 ± 3.9% in LDL-C and - 13.9 ± 5.8% in LDL-C/HDL. The safety profiles were unaffected.

conclusionsAG extract added to conventional treatment provided an effective and safe adjunct in the management of T2DM. Larger studies using physiologically standardized ginseng preparations are warranted to substantiate the present findings and to demonstrate therapeutic effectiveness of AG. CLINICALTRIALS. GOV IDENTIFIER: NCT02923453.

Indexed as

PanaxAgedBlood GlucoseCardiovascular DiseasesCross-Over StudiesDiabetes Mellitus, Type 2Double-Blind MethodFemaleHumansHypoglycemic AgentsInsulinMaleMiddle AgedPlant ExtractsRisk FactorsTreatment OutcomeBlood GlucoseHypoglycemic AgentsInsulinPlant ExtractsBlood glucoseBlood pressureCholesterolDiabetes mellitusGinsengPanax quinquefolius

Identifiers

PMID29478187
OpenAlexW2789003854

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.