ArticleBrain structure & function2018
Integration of transcriptomic and cytoarchitectonic data implicates a role for MAOA and TAC1 in the limbic-cortical network.
Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
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- Integrated 3D Modeling and Functional Simulation of the Human Amygdala: A Novel Anatomical and Computational Analyses.Neuroinformatics · 2025Article
- Structural Connectivity Differences Reflect Microstructural Heterogeneity of the Human Insular Cortex.Human brain mapping · 2025Article
- Transcriptomic gradients of the human cerebellum.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Digital tools of analysis and data integration facilitate synergy between mouse and human brain research and enable translation.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Transcriptomic contributions to a modern cytoarchitectonic parcellation of the human cerebral cortex.Brain structure & function · 2024Article
- Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns.BMC medicine · 2023Article
- Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus.NeuroImage · 2023Article
- Characterization of the angular gyrus in an older adult population: a multimodal multilevel approach.Brain structure & function · 2023Article
- Brain Structure and Function: the first 15 years-a retrospective.Brain structure & function · 2021Article
- Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures.Nature communications · 2021Article
- Exploring the secrets of brain transcriptional regulation: developing methodologies, recent significant findings, and perspectives.Brain structure & function · 2021Review
- Advanced brain ageing in Parkinson's disease is related to disease duration and individual impairment.Brain communications · 2021Article
- Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.Frontiers in neuroscience · 2021Article
- Gray matter volume and estimated brain age gap are not linked with sleep-disordered breathing.Human brain mapping · 2020Article
- Human visual cortex is organized along two genetically opposed hierarchical gradients with unique developmental and evolutionary origins.PLoS biology · 2019Article
- Multi-modal brain data exploration software for imaging transcriptomics: A comparative evaluation and future directions.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Decoding the chain from genes to cognition requires detailed insights how areas with specific gene activities and microanatomical architectures contribute to brain function and dysfunction. The Allen Human Brain Atlas contains regional gene expression data, while the JuBrain Atlas offers three-dimensional cytoarchitectonic maps reflecting interindividual variability. To date, an integrated framework that combines the analytical benefits of both scientific platforms towards a multi-level brain atlas of adult humans was not available. We have, therefore, developed JuGEx, a new method for integrating tissue transcriptome and cytoarchitectonic segregation. We investigated differential gene expression in two JuBrain areas of the frontal pole that we have structurally and functionally characterized in previous studies. Our results show a significant upregulation of MAOA and TAC1 in the medial area frontopolaris which is a node in the limbic-cortical network and known to be susceptible for gray matter loss and behavioral dysfunction in patients with depression. The MAOA gene encodes an enzyme which is involved in the catabolism of dopamine, norepinephrine, serotonin, and other monoaminergic neurotransmitters. The TAC1 locus generates hormones that play a role in neuron excitations and behavioral responses. Overall, JuGEx provides a new tool for the scientific community that empowers research from basic, cognitive and clinical neuroscience in brain regions and disease models with regard to gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.