SynthesisEuropean journal of nuclear medicine and molecular imaging2018
FDG-PET/CT for treatment response assessment in head and neck squamous cell carcinoma: a systematic review and meta-analysis of diagnostic performance.
Synthesis in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Added value of 3'-deoxy-3'-[Annals of medicine · 2025Pooled it
- Diagnostic accuracy of NI-RADS for prediction of head and neck squamous cell carcinoma: a systematic review and meta-analysis.La Radiologia medica · 2024Pooled it
- A narrative review: key evidence from meta-analyses in nuclear medicine.Annals of nuclear medicine · 2026Review
- Post-Radiation PET Shows Higher Diagnostic Accuracy in HPV-Negative Head and Neck Cancers.Cancers · 2026Article
- Diagnostic Accuracy of PET/CT and Diffusion-weighted MRI in Detecting Residual Oropharyngeal Carcinoma after Chemoradiotherapy.Radiology. Imaging cancer · 2026Article
- Prognostic significance of intermediate and high SUVmax values and imaging timing on FDG-PET/CT after radiation therapy in HNSCC: a retrospective cohort study.Frontiers in oncology · 2026Article
- FDG PET Hybrid Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Review
- AssessingNuclear medicine and molecular imaging · 2025Article
- Role ofCancers · 2024Review
- An Intensive 18F-Fludeoxyglucose-Positron Emission Tomography With Computed Tomography-Based Strategy of Follow-Up in Patients Treated for Head and Neck Squamous Cell Carcinoma Who Are Clinically Asymptomatic.JAMA network open · 2023Article
- Imaging of human papilloma virus associated oropharyngeal squamous cell carcinoma and its impact on diagnosis, prognostication, and response assessment.The British journal of radiology · 2022Review
- Combined PET-CT and MRI for response evaluation in patients with squamous cell anal carcinoma treated with curative-intent chemoradiotherapy.European radiology · 2022Article
- Dual time point imaging in locally advanced head and neck cancer to assess residual nodal disease after chemoradiotherapy.EJNMMI research · 2022Article
- Predicting local persistence/recurrence after radiation therapy for head and neck cancer from PET/CT using a multi-objective, multi-classifier radiomics model.Frontiers in oncology · 2022Article
- End of treatment cone-beam computed tomography (CBCT) is predictive of radiation response and overall survival in oropharyngeal squamous cell carcinoma.Radiation oncology (London, England) · 2021Article
- The ability of post-chemoradiotherapy DWI ADCJournal of cancer research and clinical oncology · 2021Observational
- Correlations between DW-MRI andCancer reports (Hoboken, N.J.) · 2021Observational
- Clinical perspectives for the use of total body PET/CT.European journal of nuclear medicine and molecular imaging · 2021Article
- Improving post-CRT neck assessment in patients with HPV-associated OPSCC (Review).Molecular and clinical oncology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purpose18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is increasingly used to evaluate treatment response in head and neck squamous cell carcinoma (HNSCC). This analysis assessed the diagnostic value of FDG-PET/CT in detecting nodal disease within 6 months after treatment, considering patient and disease characteristics.
methodsA systematic review was performed using the MEDLINE and Web of Knowledge databases. The results were pooled using a bivariate random effects model of the sensitivity and specificity.
resultsOut of 22 identified studies, a meta-analysis of 20 studies (1293 patients) was performed. The pooled estimates of sensitivity, specificity and diagnostic odds ratio (with 95% CI) were 85% (76-91%), 93% (89-96%) and 76 (35-165), respectively. With the prevalence set at 10%, the positive and negative predictive values were 58% and 98%. There was significant heterogeneity between the trials (p < 0.001). HPV positive tumors were associated with lower sensitivity (75% vs 89%; p = 0.01) and specificity (87% vs 95%; p < 0.005).
conclusionFDG-PET/CT within 6 months after (chemo)radiotherapy in HNSCC patients is a reliable method for ruling out residual/recurrent nodal disease and obviates the need for therapeutic intervention. However, FDG-PET/CT may be less reliable in HPV positive tumors and the optimal surveillance strategy remains to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.