ArticleEnvironment international2018
Preconception and prenatal urinary concentrations of phenols and birth size of singleton infants born to mothers and fathers from the Environment and Reproductive Health (EARTH) study.
Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00011713 (Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Gestational triclosan exposure and infant birth weight: A systematic review and meta-analysis.Environment international · 2021Pooled it
- Effect of Maternal Triclosan Exposure on Neonatal Birth Weight and Children Triclosan Exposure on Children's BMI: A Meta-Analysis.Frontiers in public health · 2021Pooled it
- The banned sunscreen ingredients and their impact on human health: a systematic review.International journal of dermatology · 2020Pooled it
- Paternal Exposure to Endocrine Disrupting Chemicals and Couples' Pregnancy Outcomes: A Qualitative Review of the Literature.Current environmental health reports · 2026Review
- The influence of paternal preconception health on birth defects and head circumference: A scoping review.PLOS global public health · 2026Article
- The influence of paternal preconception health on infant birth weight: A scoping review.PloS one · 2026Article
- Review
- Beyond Genes: Mechanistic and Epidemiological Insights into Paternal Environmental Influence on Offspring Health.Current environmental health reports · 2025Review
- Endocrine and Reproductive Health Considerations of Sunscreen UV Filters: Insights from a Comprehensive Review 2014-2024.Current environmental health reports · 2025Review
- Impact of paraben on uterine collagen: An integrated and targeted Correlative approach using second harmonic generation microscopy, nanoindentation, and atomic force microscopy.Journal of the mechanical behavior of biomedical materials · 2025Article
- Review
- Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep.Environmental toxicology and pharmacology · 2023Article
- Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population.Scientific reports · 2023Article
- Prenatal exposure to polybrominated diphenyl ethers and inattention/hyperactivity symptoms in mid to late adolescents.Frontiers in epidemiology · 2023Article
- Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps.Environment international · 2022Review
- Maternal diet quality moderates associations between parabens and birth outcomes.Environmental research · 2022Article
- Association of preconception mixtures of phenol and phthalate metabolites with birthweight among subfertile couples.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- The association of prenatal exposure to benzophenones with gestational age and offspring size at birth.Environmental science and pollution research international · 2022Article
- Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Anything New about Paternal Contribution to Reproductive Outcomes? A Review of the Evidence.The world journal of men's health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAlthough pregnancy concentrations of some phenols have been associated with infant size at birth, there is limited data on the effect of preconception exposure.
objectiveWe aimed to examine paternal and maternal preconception and maternal prenatal urinary phenol concentrations in relation to birth weight and head circumference.
methodsWe evaluated 346 singletons born to 346 mothers and 184 fathers (184 couples) from a prospective preconception cohort of subfertile couples from the Environment and Reproductive Health (EARTH) Study in Boston, USA. We used multiple urine samples collected before the index pregnancy in both men and women to estimate mean preconception urinary benzophenone-3, triclosan, butylparaben, propylparaben, methylparaben, or ethylparaben concentrations. We also estimated mean maternal prenatal urinary phenol concentrations by averaging trimester-specific urine samples. Birth weight and head circumference were abstracted from delivery records. We estimated the association of natural log-phenol concentrations with birth outcomes using multivariable linear regression models, adjusting for known confounders.
resultsIn adjusted models, each log-unit increase in paternal preconception benzophenone-3 concentration was associated with a 137 g increase in birth weight (95% CI: 60, 214). Additional adjustment for prenatal benzophenone-3 concentration strengthened this association. None of the maternal preconception phenol concentrations were associated with birth weight. However, maternal prenatal triclosan concentrations were associated with a 38 g decrease in birth weight (95% CI: -76, 0). Few associations were observed between phenols and head circumference except for a decrease of 0.27 cm (95% CI: -54, 0) in relation to maternal preconception methylparaben concentration.
conclusionsAlthough our findings should be interpreted in light of inherent study limitations, these results suggest potential evidence of associations between some paternal or maternal phenol concentrations and birth size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.