ArticleJournal of affective disorders2018
Evidence for association between familial bipolar risk and ventral striatal volume.
Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Human Connectome Project: A retrospective.NeuroImage · 2021Review
- Rostral Middle Frontal Volumetric Differences in Bipolar Offspring versus Community Controls Offspring.International journal of psychological researchArticle
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
backgroundRecent genome-wide association studies (GWAS) of striatal volumes and bipolar disorder (BD) indicate these traits are heritable and share common genetic architecture, however little independent work has been conducted to help establish this relationship.
methodsSubcortical volumes (mm
resultsAfter multiple comparison correction, there was a regional and BD specific relationship in the direction expected (Accumbens: F DISCUSSION: In line with recent GWAS, there was evidence supporting the hypothesis that reduced striatal volume may be part of the genetic risk for BD, but not MDD. LIMITATIONS: It cannot be concluded whether this association was specific to BD or consistent with a broader psychosis phenotype, due to a small sample size for offspring of schizophrenia patients. Furthermore, one cannot rule out potential shared environmental influences of parental BD.
conclusionsThe common genetic architecture of BD may confer susceptibility via inherited genetic factors that affect striatal volume. Future work should establish how this relationship relates to specific BD symptomology. This work may also help to dissect clinical heterogeneity and improve diagnosis nosology.
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