ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2018
Incidence, risk factors, and clinical implications of post-operative delirium in lung transplant recipients.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Postoperative Neurocognitive Disorders in Cardiac Surgery: Investigating the Role of Intraoperative Hypotension. A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- A Systematic Review of Delirium Biomarkers and Their Alignment with the NIA-AA Research Framework.Journal of the American Geriatrics Society · 2021Pooled it
- Trial
- Importance of psychiatric evaluation and long-term outcomes of delirium in lung transplant recipients.Annals of medicine · 2026Article
- Meta-analysis of the incidence and risk factors of postoperative delirium in organ transplant patients.World journal of psychiatry · 2025Article
- Assessment of postoperative outcomes of prescription benzodiazepine use in lung transplant recipients.Journal of thoracic disease · 2025Article
- Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration.Frontiers in aging neuroscience · 2025Review
- Influence of perioperative blood pressure regulation on postoperative delirium in patients undergoing head and neck free flap reconstruction.European journal of medical research · 2023Article
- Perioperative cognition in association with malnutrition and frailty: a narrative review.Frontiers in neuroscience · 2023Review
- Emergence delirium and postoperative delirium associated with high plasma NfL and GFAP: an observational study.Frontiers in medicine · 2023Article
- Medical Complications of Lung Transplantation.Journal of chest surgery · 2022Article
- Non-pulmonary complications after lung transplantation: Part I.Indian journal of thoracic and cardiovascular surgery · 2022Review
- The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation.Clinical transplantation · 2021Article
- Clinical and Neuroimaging Correlates of Post-Transplant Delirium.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020Article
- Medically Induced Exacerbation of PTSD Following Lung Transplantation: A Case Series.Journal of clinical psychology in medical settings · 2020Article
- Cerebral complications of solid organ transplantation.Intensive care medicine · 2019Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDelirium significantly affects post-operative outcomes, but the incidence, risk factors, and long-term impact of delirium in lung transplant recipients have not been well studied.
methodsWe analyzed 155 lung transplant recipients enrolled in the Lung Transplant Outcomes Group (LTOG) cohort at a single center. We determined delirium incidence by structured chart review, identified risk factors for delirium, determined whether plasma concentrations of 2 cerebral injury markers (neuron-specific enolase [NSE] and glial fibrillary acidic protein [GFAP]) were associated with delirium, and determined the association of post-operative delirium with 1-year survival.
resultsFifty-seven (36.8%) patients developed post-operative delirium. Independent risk factors for delirium included pre-transplant benzodiazepine prescription (relative risk [RR] 1.82; 95% confidence interval [CI] 1.08 to 3.07; p = 0.025), total ischemic time (RR 1.10 per 30-minute increase; 95% CI 1.01 to 1.21; p = 0.027), duration of time with intra-operative mean arterial pressure <60 mm Hg (RR 1.07 per 15-minute increase; 95% CI 1.00 to 1.14; p = 0.041), and Grade 3 primary graft dysfunction (RR 2.13; 95% CI 1.27 to 3.58; p = 0.004). Ninety-one (58.7%) patients had plasma available at 24 hours. Plasma GFAP was inconsistently detected, whereas NSE was universally detectable, with higher NSE concentrations associated with delirium (risk difference 15.1% comparing 75th and 25th percentiles; 95% CI 2.5 to 27.7; p = 0.026). One-year mortality appeared higher among delirious patients, 12.3% compared with 7.1%, but the difference was not significant (p = 0.28).
conclusionsPost-operative delirium is common in lung transplant recipients, and several potentially modifiable risk factors deserve further study to determine their associated mechanisms and predictive values.
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