Evidence map›Paper›PMID 29477372›Full record

Trial reportDisability and health journal2018

Computer-assisted cognitive rehabilitation in persons with multiple sclerosis: Results of a multi-site randomized controlled trial with six month follow-up.

Alexa K Stuifbergen, Heather Becker, Francisco Perez, Janet Morrison, Adama Brown, Vicki Kullberg, Wenhui Zhang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Disability and health journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Virtual reality for multiple sclerosis rehabilitation.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Use of pragmatic randomized trials in multiple sclerosis: A systematic overview.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024
    Pooled it
  3. Pooled it
  4. Memory rehabilitation for people with multiple sclerosis.The Cochrane database of systematic reviews · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexa K StuifbergenSchool of Nursing, The University of Texas at Austin, USA. Electronic address: astuifbergen@mail.utexas.edu.
Heather BeckerSchool of Nursing, The University of Texas at Austin, USA.
Francisco PerezSchool of Nursing, The University of Texas at Austin, USA.
Janet MorrisonSchool of Nursing, The University of Texas at Austin, USA.
Adama BrownSchool of Nursing, The University of Texas at Austin, USA.
Vicki KullbergSchool of Nursing, The University of Texas at Austin, USA.
Wenhui ZhangSchool of Nursing, The University of Texas at Austin, USA.

Funding

A Multi-Site Trial of a Cognitive Rehabilitation Intervention for Persons with MSR01NR014362 · NINR · UNIVERSITY OF TEXAS AT AUSTIN · PI BECKER, HEATHER A, STUIFBERGEN, ALEXA · 2013 to 2017
$2.2M
NINR NIH HHS R01 NR014362
6 · The paper itself

Abstract

backgroundThe effects of multiple sclerosis (MS) on cognition have gained increasing recognition as one of the major disabling symptoms of the disease. Despite the prevalence of these symptoms and their impact on quality of life, limited attention has been given to strategies that might help manage the cognitive changes commonly experienced by persons with MS.

objectiveThe primary purpose of this study was to determine the effectiveness of a novel computer-assisted cognitive rehabilitation intervention MAPSS-MS (Memory, Attention, Problem Solving Skills in MS) in a multi-site trial with persons with MS.

methodsPersons with MS (N = 183) with cognitive concerns were randomly assigned to either the 8-week MAPSS-MS intervention or usual care plus freely available computer games. Participants completed self-report and performance measures of cognitive functioning, compensatory strategies and depression at baseline, immediately after the MAPSS-MS intervention, and three and six months post-intervention. Changes in study outcomes were analyzed using intention to treat methodology, ANOVA with repeated measures, and ANCOVA.

resultsBoth groups improved significantly on all outcome measures. The intervention group outperformed the comparison group on all measures, and there were statistically significant differences on selected measures.

conclusionFindings suggest that MAPSS-MS is a feasible intervention that could be broadly implemented in community settings. It has been shown to be modestly successful in improving cognitive functioning.

Indexed as

CognitionAdultAttentionCognitive DysfunctionComputer-Assisted InstructionDepressionFemaleFollow-Up StudiesHumansMaleMemoryMemory DisordersMiddle AgedMultiple SclerosisPersons with DisabilitiesProblem SolvingCognitive rehabilitationMultiple sclerosisRandomized controlled trial

Identifiers

PMID29477372
PMCPMC6047944

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.