ArticleColloids and surfaces. B, Biointerfaces2018
Branched polyrotaxane hydrogels consisting of alpha-cyclodextrin and low-molecular-weight four-arm polyethylene glycol and the utility of their thixotropic property for controlled drug release.
Article in Colloids and surfaces. B, Biointerfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Impact of polymer source variations on hydrogel structure and product performance in dexamethasone-loaded ophthalmic inserts.International journal of pharmaceutics · 2025Article
- 3D Bioprinting Highly Elastic PEG-PCL-DA Hydrogel for Soft Tissue Fabrication and Biomechanical Stimulation.Advanced functional materials · 2024Article
- The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives.Pharmaceutics · 2023Review
- Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects.Gels (Basel, Switzerland) · 2023Review
- Glaucoma Treatment and Hydrogel: Current Insights and State of the Art.Gels (Basel, Switzerland) · 2022Review
- Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment.Pharmaceutics · 2021Review
- Tough and Resilient Hydrogels Enabled by a Multifunctional Initiating and Cross-Linking Agent.Gels (Basel, Switzerland) · 2021Article
- Toward a Greener World-Cyclodextrin Derivatization by Mechanochemistry.Molecules (Basel, Switzerland) · 2021Review
- "Double-punch" strategy for delivery of viral immunotherapy with prolonged tumor retention and enhanced transfection efficacy.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis.Science advances · 2020Article
- Drug-loaded chitosan film prepared via facile solution casting and air-drying of plain water-based chitosan solution for ocular drug delivery.Bioactive materials · 2020Article
- Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications.Molecules (Basel, Switzerland) · 2020Review
- α-Cyclodextrin-Based Polypseudorotaxane Hydrogels.Materials (Basel, Switzerland) · 2019Review
- Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations.Journal of controlled release : official journal of the Controlled Release Society · 2019Review
- New injectable two-step forming hydrogel for delivery of bioactive substances in tissue regeneration.Regenerative biomaterials · 2019Article
- Injectable Hydrogels for Cardiac Tissue Engineering.Macromolecular bioscience · 2018Review
- Thermoadaptive Supramolecular α-Cyclodextrin Crystallization-Based Hydrogels via Double Hydrophilic Block Copolymer Templating.Polymers · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In this work, we developed a new class of branched polyrotaxane hydrogel made of 4-arm polyethylene glycol (4-PEG) and α-cyclodextrin (α-CD) using supramolecular host-guest interactions as a cross-linking strategy. Because of the dynamic nature of the non-covalent host-guest cross-linking, the resulting supramolecular α-CD/4-PEG hydrogels show thixotropic behavior and undergo a reversible gel-sol transition in response to shear stress change. We loaded the antiglaucoma drug brimonidine into the α-CD/4-PEG gel and found the drug release kinetics was controlled by shear stress. This thixotropic shear thinning property makes the supramolecular hydrogels highly attractive in drug delivery applications and suitable for preparation of injectable drug formulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.