Evidence map›Paper›PMID 29476920›Full record

ArticleFree radical biology & medicine2018

Analysis of eicosanoid oxidation products in Alzheimer brain by LC-MS with uniformly 13C-labeled internal standards.

Ran Furman, Jin V Lee, Paul H Axelsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Eicosanoids metabolized through LOX distinguish asthma-COPD overlap from COPD by metabolomics study.International journal of chronic obstructive pulmonary disease · 2019
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ran FurmanDepartment of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States.
Jin V LeeDepartment of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States.
Paul H AxelsenDepartment of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States; Departments of Biochemistry and Biophysics, and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States. Electronic address: axe@pharm.med.upenn.edu.
University of Pennsylvania · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Structure determination by vibrational spectroscopyR01GM076201 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI AXELSEN, PAUL H · 2007 to 2018
$3.2M
Posttranslational Protein Modification in Alzheimer PathologyRF1AG057197 · NIA · UNIVERSITY OF PENNSYLVANIA · PI AXELSEN, PAUL H · 2018 to 2018
$2.0M
Oxidative lipid stress in the brainR01NS074178 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AXELSEN, PAUL H · 2011 to 2015
$1.7M
NIA NIH HHS R01 AG057197NIA NIH HHS RF1 AG057197NIEHS NIH HHS P30 ES013508NIGMS NIH HHS R01 GM076201NINDS NIH HHS R01 NS074178
6 · The paper itself

Abstract

The quantitative analysis of polyunsaturated fatty acyl (PUFA) chain oxidation products in tissue samples by mass spectrometry is hindered by the lack of durable internal standards for the large number of possible products. To address this problem in a study of oxidative PUFA degradation in Alzheimer's disease (AD) brain, uniformly

Indexed as

Brain ChemistryAgedAged, 80 and overAlzheimer DiseaseAnimalsCarbon IsotopesChromatography, LiquidEicosanoidsFemaleHumansMaleMiceOxidation-ReductionTandem Mass SpectrometryCarbon-13Carbon IsotopesEicosanoidsAlzheimer's diseaseBrainEicosanoidsLipid PeroxidationMass spectrometryOxidized Lipids

Identifiers

PMID29476920
PMCPMC5884722
OpenAlexW2791752256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.