ReviewNeuroscience and biobehavioral reviews2018
Subliminal (latent) processing of pain and its evolution to conscious awareness.
Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Differential Operant Conditioning of Emotional-Motivational and Sensory-Discriminative Pain Responses.European journal of pain (London, England) · 2026Article
- Consciousness Research Through Pain.Healthcare (Basel, Switzerland) · 2025Review
- Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study.The journal of headache and pain · 2024Article
- Research on the multidimensional brain remodeling mechanisms at the level of brain regions, circuits, and networks in patients with chronic lower back pain caused by lumbar disk herniation.Frontiers in neuroscience · 2024Article
- Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders.The journal of headache and pain · 2023Observational
- Neurokinin receptor mechanisms in forebrain medial septum modulate nociception in the formalin model of inflammatory pain.Scientific reports · 2021Article
- Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain.The ocular surface · 2021Article
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Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.