ArticleMedicina oral, patologia oral y cirugia bucal2018
Oral cancer associated with chronic mechanical irritation of the oral mucosa.
Article in Medicina oral, patologia oral y cirugia bucal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Chronic mechanical trauma/irritation and oral carcinoma: A systematic review showing low evidence to support an association.Oral diseases · 2022Pooled it
- The Clinicodemographic Features of Oral Squamous Cell Carcinoma: A Single-Centre Retrospective Study.International journal of dentistry · 2026Article
- Tongue cancer in pregnancy: challenges and outcomes. A case series and review of the literature.Oral and maxillofacial surgery · 2025Review
- Development of Subcritical Water Extraction for Areca Alkaloids and Its Influence on the Structure of Areca Nut Husk.Molecules (Basel, Switzerland) · 2025Article
- Socio-demographic disparities in global trends of lip and oral cavity neoplasms from 1990 to 2021.Scientific reports · 2025Article
- The Effect of Oral Potentially Malignant Disorders (OPMD) on Dental Implants Survival-A Systematic Review.Dentistry journal · 2025Review
- Assessment of various etiological factors for oral squamous cell carcinoma in non-habit patients- a cross sectional case control study.BMC oral health · 2025Article
- A multimodal approach for establishingFrontiers in pharmacology · 2025Article
- Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs.Nutrients · 2024Review
- Increased prevalence of oral potentially malignant lesions among Croatian War invalids, a cross-sectional study.Journal of clinical and experimental dentistry · 2023Article
- Hamular bursitis as a cause of orofacial pain. A case report.Journal of clinical and experimental dentistry · 2023Article
- Chronic mechanical irritation enhances the effect of tobacco and alcohol on the risk of oral squamous cell carcinoma: a case-control study in Argentina.Clinical oral investigations · 2022Article
- Molecular Research on Oral Diseases and Related Biomaterials: A Journey from Oral Cell Models to Advanced Regenerative Perspectives.International journal of molecular sciences · 2022Review
- Oral squamous cell carcinoma with essential thrombocythemia and positive JAK2 (V617F) mutation.Journal of Taibah University Medical Sciences · 2022Article
- Squamous cell carcinoma around a subperiosteal implant in the maxilla and the association of chronic mechanical irritation and peri-implantitis: a case report.International journal of implant dentistry · 2022Article
- Effect of the accumulation of risk factors on the risk of oral squamous cell carcinomaRevista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2021Article
- Cytogenetic analysis of genetic damage in young individuals exposed to chronic mechanical irritation in the lateral border of the tongue due to sharp teeth - a novel study.Medicine and pharmacy reports · 2021Article
- Autophagy-A Hidden but Important Actor on Oral Cancer Scene.International journal of molecular sciences · 2020Review
- Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers.Medicina oral, patologia oral y cirugia bucal · 2020Article
- YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.Science advances · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost of the studies dealing with Chronic Mechanical Irritation (CMI) and Oral Cancer (OC) only considered prosthetic and dental variables separately, and CMI functional factors are not registered. Thus, the aim of this study was to assess OC risk in individuals with dental, prosthetic and functional CMI. Also, we examined CMI presence in relation to tumor size. MATERIAL AND
methodsA case-control study was carried out from 2009 to 2013. Study group were squamous cell carcinoma cases; control group was patients seeking dental treatment in the same institution.
results153 patients were studied (Study group n=53, Control group n=100). CMI reproducibility displayed a correlation coefficient of 1 (p<0.0001). Bivariate analysis showed statistically significant associations for all variables (age, gender, tobacco and alcohol consumption and CMI). Multivariate analysis exhibited statistical significance for age, alcohol, and CMI, but not for gender or tobacco. Relationship of CMI with tumor size showed no statistically significant differences.
conclusionsCMI could be regarded as a risk factor for oral cancer. In individuals with other OC risk factors, proper treatment of the mechanical injuring factors (dental, prosthetic and functional) could be an important measure to reduce the risk of oral cancer.
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Registered trials
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