ArticleJournal of clinical periodontology2018
Ageing effects on humoral immune responses in chronic periodontitis.
Article in Journal of clinical periodontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Pooled it
- Taxonomic and functional signatures of smoking and periodontitis severity in the subgingival microbiome of older adults.npj aging · 2025Article
- Oral Microbiota Linking Humoral Response, Periodontitis and Atherosclerosis.Journal of clinical periodontology · 2025Article
- Joint association of triglyceride glucose index (TyG) and body roundness index with the risk of periodontitis: a cross-sectional study.Frontiers in nutrition · 2025Article
- Non-Surgical Periodontal Therapy's Influence on Alpha-Synuclein and Inflammatory Marker Levels: A Pilot Study.Journal of clinical medicine · 2024Article
- Association of dietary zinc consumption with periodontitis in diabetes mellitus patients: A cross-sectional study of national health and nutrition examination surveys database (2009-2014).Journal of dental sciences · 2024Article
- Relationship between serum uric acid levels and periodontitis-A cross-sectional study.PloS one · 2024Article
- Periodontal pathogens and obesity in the context of cardiovascular risks across age groups.Frontiers in oral health · 2024Article
- Breaking the Gingival Barrier in Periodontitis.International journal of molecular sciences · 2023Review
- Relationship between different skeletal facial types and anterior alveolar bone thickness with cone-beam computed tomography in an Asian population.Annals of translational medicine · 2022Article
- Immunoglobulin Disorders and the Oral Cavity: A Narrative Review.Journal of clinical medicine · 2022Review
- Identification and validation of a classifier based on hub aging-related genes and aging subtypes correlation with immune microenvironment for periodontitis.Frontiers in immunology · 2022Article
- Tooth Loss and Blood Pressure in Parkinson's Disease Patients: An Exploratory Study on NHANES Data.International journal of environmental research and public health · 2021Article
- Article
- Upregulating the Expression of LncRNA ANRIL Promotes Osteogenesis via the miR-7-5p/IGF-1R Axis in the Inflamed Periodontal Ligament Stem Cells.Frontiers in cell and developmental biology · 2021Article
- The Oral Microbiome in Periodontal Health.Frontiers in cellular and infection microbiology · 2021Article
- Parkinson's Disease, Periodontitis and Patient-Related Outcomes: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2020Article
- Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson's Disease Patients: Data from the NHANES 2011-2012.Journal of personalized medicine · 2020Article
- Heterogeneity of human serum antibody responses to P. gingivalis in periodontitis: Effects of age, race/ethnicity, and sex.Immunology letters · 2020Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Periodontal disease is a dominant global bacterial infection that increases with ageing.
aimThis report focuses on host adaptive immune responses in periodontitis. While experimental models and humans diagnosed with periodontitis demonstrate an antigenic specificity for particular oral bacteria, we have a limited understanding of (i) how ageing affects the adaptive immune responses to these bacteria that chronically colonize the oral cavity for decades prior to disease expression and (ii) how the magnitude and specificity of the response interface with pathogens that emerge within the bacterial ecology during exacerbations of disease. MATERIALS AND
methodsSerum antibody levels to a group of pathogenic and commensal oral bacteria were measured in a population of individuals from 21 to 74 years of age, stratified based on clinical status of the periodontium, smoking and sex.
resultsClinical parameters were not significantly different within health, gingivitis or periodontitis groups related to age. Antibody to oral pathogens and commensals was similar in different age groups in each of the clinical categories, with no age correlation noted in the periodontitis patients.
conclusionsThe adaptive immune responses to oral bacteria that chronically colonize the oral cavity appear generally unaffected by age, but clearly are linked to the extent of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.