Evidence map›Paper›PMID 29476405›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2018

PRSS1 (R122H) mutation in an Indian family with low penetrance is associated with pancreatitis phenotype.

Urmila Steffie Avanthi, Govardhan Bale, Mohsin Aslam, Rupjyoti Talukdar, Nageshwar Reddy Duvvur, Ravikanth Venkata Vishnubhotla

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In one paragraph

Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Progression of recurrent acute to chronic pancreatitis: More questions than answers!Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Urmila Steffie AvanthiAsian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad, 500 076, India.
Govardhan BaleAsian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad, 500 076, India.
Mohsin AslamAsian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad, 500 076, India.
Rupjyoti TalukdarAsian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad, 500 076, India.
Nageshwar Reddy DuvvurAsian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad, 500 076, India.
Ravikanth Venkata VishnubhotlaAsian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad, 500 076, India. ravikanth.aig@gmail.com.ORCID http://orcid.org/0000-0001-6970-0169
Asian Institute of Gastroenterology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in PRSS1 gene namely R122H and N29I cause hereditary pancreatitis. They are autosomal dominant with a high penetrance (80%) reported in North American, North-east Asian, and North European ethnicities. However, the mutations are reportedly absent in Indian, African, and South American ethnicities. We report here for the first time a family from India that is positive for R122H mutation in the PRSS1 gene. The proband is symptomatic with chronic pancreatitis, however, the father although heterozygous for R122H is asymptomatic.

Indexed as

MutationPenetranceAsian PeopleChildFemaleGenes, DominantHeterozygoteHumansIndiaPancreatitis, ChronicTrypsinPRSS1 protein, humanTrypsinHereditary pancreatitisLow penetrancePRSS1R122H mutation

Identifiers

PMID29476405
OpenAlexW2791511790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.