ArticleDysphagia2018
Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model.
Article in Dysphagia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Primate Swallowing Is Powered by Both Rotation and Contraction of Suprahyoid Muscles.American journal of biological anthropology · 2026Article
- Mechanisms of Improving Feeding Function With Capsaicin Following Local Anesthesia in Infant Pigs.The Laryngoscope · 2025Article
- Research advances in dysphagia animal models.Animal models and experimental medicine · 2025Review
- Longitudinal Changes in Aerodigestive Responses to Varying Nipple Properties in Infant Pigs.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Dendritic alterations precede age-related dysphagia and nucleus ambiguus motor neuron death.The Journal of physiology · 2025Article
- Exploring the interaction of viscosity and nipple design on feeding performance in an infant pig model.Journal of texture studies · 2023Article
- Impact of volume and rate of milk delivery on coordination of respiration and swallowing in infant pigs.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Evaluating The Precocial-altricial Axis of Motor Skill at Birth in A Preterm Pig Model.Integrative and comparative biology · 2023Article
- Developmental factors influencing bone strength in precocial mammals: An infant pig model.Journal of anatomy · 2023Article
- The effect of stiffness and hole size on nipple compression in infant suckling.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Oropharyngeal capsaicin exposure improves infant feeding performance in an animal model of superior laryngeal nerve damage.Journal of neurophysiology · 2022Article
- Increased viscosity of milk during infant feeding improves swallow safety through modifying sucking in an animal model.Journal of texture studies · 2021Article
- Swallow Safety is Determined by Bolus Volume During Infant Feeding in an Animal Model.Dysphagia · 2021Article
- Does birth weight affect neonatal body weight, growth, and physiology in an animal model?PloS one · 2021Article
- Sucking versus swallowing coordination, integration, and performance in preterm and term infants.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Muscle activity and kinematics show different responses to recurrent laryngeal nerve lesion in mammal swallowing.Journal of neurophysiology · 2020Article
- Article
- The effect of preterm birth, recurrent laryngeal nerve lesion, and postnatal maturation on hyoid and thyroid movements, and their coordination in infant feeding.Journal of biomechanics · 2020Article
- Changes in the coordination between respiration and swallowing from suckling through weaning.Biology letters · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
The timing of the occurrence of a swallow in a respiratory cycle is critical for safe swallowing, and changes with infant development. Infants with damage to the recurrent laryngeal nerve, which receives sensory information from the larynx and supplies the intrinsic muscles of the larynx, experience a significant incidence of dysphagia. Using our validated infant pig model, we determined the interaction between this nerve damage and the coordination between respiration and swallowing during postnatal development. We recorded 23 infant pigs at two ages (neonatal and older, pre-weaning) feeding on milk with barium using simultaneous high-speed videofluoroscopy and measurements of thoracic movement. With a complete linear model, we tested for changes with maturation, and whether these changes are the same in control and lesioned individuals. We found (1) the timing of swallowing and respiration coordination changes with maturation; (2) no overall effect of RLN lesion on the timing of coordination, but (3) a greater magnitude of maturational change occurs with RLN injury. We also determined that animals with no surgical intervention did not differ from animals that had surgery for marker placement and a sham procedure for nerve lesion. The coordination between respiration and swallowing changes in normal, intact individuals to provide increased airway protection prior to weaning. Further, in animals with an RLN lesion, the maturation process has a larger effect. Finally, these results suggest a high level of brainstem sensorimotor interactions with respect to these two functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.