Evidence map›Paper›PMID 29476238›Full record

Trial reportEuropean journal of nutrition2019

Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial.

Boon Chew, Bridget Mathison, Lindsey Kimble, Diane McKay, Kerrie Kaspar, Christina Khoo, C-Y Oliver Chen, Jeffrey Blumberg

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 6 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Biomarkers of Berry Intake: Systematic Review Update.Journal of agricultural and food chemistry · 2023
    Pooled it
  3. Pooled it
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  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. Article
  14. Article
  15. Effects of Cranberry Extract (Journal of nutrition and metabolism · 2024
    Article
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  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Boon ChewSchool of Food Science, Washington State University, Pullman, WA, USA. boon.chew@tamu.edu.
Bridget MathisonSchool of Food Science, Washington State University, Pullman, WA, USA.
Lindsey KimbleSchool of Food Science, Washington State University, Pullman, WA, USA.ORCID http://orcid.org/0000-0002-0319-1098
Diane McKayAntioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Kerrie KasparOcean Spray Cranberries Inc., Middleboro, MA, USA.
Christina KhooOcean Spray Cranberries Inc., Middleboro, MA, USA.
C-Y Oliver ChenAntioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Jeffrey BlumbergAntioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Tufts University · USWashington State University · US

Funding

USDA Agricultural Research Service Cooperative Agreement 1950-51000-087
6 · The paper itself

Abstract

purposeWe studied the health benefits of low calorie cranberry beverage consumption on glucoregulation, oxidative damage, inflammation, and lipid metabolism in overweight but otherwise healthy humans.

methods78 overweight or obese men and women (30-70 years; BMI 27-35 kg/m

resultsCompared to placebo, a single CEB dose at baseline lowered endothelin-1 and elevated nitric oxide and the reduced:oxidized glutathione ratio (P < 0.05). Interferon-γ was elevated (P < 0.05) after a single CEB dose at baseline; however, after 8 week of CEB intervention, fasting C-reactive protein was lower (P < 0.05). CEB consumption for 8 week also reduced serum insulin and increased HDL cholesterol compared to placebo (P < 0.05).

conclusionsAn acute dose of low calorie, high polyphenol cranberry beverage improved antioxidant status, while 8 week daily consumption reduced cardiovascular disease risk factors by improving glucoregulation, downregulating inflammatory biomarkers, and increasing HDL cholesterol.

Indexed as

BeveragesVaccinium macrocarponAdultAgedBiomarkersCholesterol, HDLDouble-Blind MethodFemaleGlucoseGlucose Tolerance TestHumansInflammationLipid MetabolismMaleMiddle AgedOverweightBiomarkersCholesterol, HDLGlucosePlant ExtractsPolyphenolsBlood glucoseCardiovascular diseaseInflammationOxidative stressVaccinium macrocarpon

Identifiers

PMID29476238
PMCPMC6499871
OpenAlexW2794248674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.