ArticleMammalian genome : official journal of the International Mammalian Genome Society2018
Leveraging human genetic and adverse outcome pathway (AOP) data to inform susceptibility in human health risk assessment.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
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- CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Risk-Based Prioritization of Organic Chemicals and Locations of Ecological Concern in Sediment From Great Lakes Tributaries.Environmental toxicology and chemistry · 2022Article
- Providing Adverse Outcome Pathways from the AOP-Wiki in a Semantic Web Format to Increase Usability and Accessibility of the Content.Applied in vitro toxicology · 2022Article
- The AOP-DB RDF: Applying FAIR Principles to the Semantic Integration of AOP Data Using the Research Description Framework.Frontiers in toxicology · 2022Article
- Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model.Frontiers in toxicology · 2022Article
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- Data Mining Approaches for Assessing Chemical Coexposures Using Consumer Product Purchase Data.Risk analysis : an official publication of the Society for Risk Analysis · 2021Article
- The 2021 update of the EPA's adverse outcome pathway database.Scientific data · 2021Article
- The Impact of Environmental Factors on Monogenic Mendelian Diseases.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Collaborative efforts are needed among the scientific community to advance the adverse outcome pathway concept in areas of radiation risk assessment.International journal of radiation biology · 2021Article
- Leveraging the Comparative Toxicogenomics Database to Fill in Knowledge Gaps for Environmental Health: A Test Case for Air Pollution-induced Cardiovascular Disease.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Modernization of chemical risk assessment to make use of novel toxicological data.Toxicology and applied pharmacology · 2020Article
- Public data sources to support systems toxicology applications.Current opinion in toxicology · 2019Article
- Optimization of a Deep-Learning Method Based on the Classification of Images Generated by Parameterized Deep Snap a Novel Molecular-Image-Input Technique for Quantitative Structure-Activity Relationship (QSAR) Analysis.Frontiers in bioengineering and biotechnology · 2019Article
- Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- In silico toxicology: From structure-activity relationships towards deep learning and adverse outcome pathways.Wiley interdisciplinary reviews. Computational molecular scienceReview
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Estimation of susceptibility differences in human health risk assessment (HHRA) has been challenged by a lack of available susceptibility and variability data after exposure to a specific environmental chemical or pharmaceutical. With the increasingly large number of available data sources that contain polymorphism and other genetic data, human genetic variability that informs susceptibility can be better incorporated into HHRA. A recent policy, the 2016 The Frank R. Lautenberg Chemical Safety for the twenty-first Century Act, requires the US Environmental Protection Agency to evaluate new and existing toxic chemicals with explicit consideration of susceptible populations of all types (life stage, exposure, genetic, etc.). We propose using the adverse outcome pathway (AOP) construct to organize, identify, and characterize human genetic susceptibility in HHRA. We explore how publicly available human genetic datasets can be used to gain mechanistic understanding of molecular events and characterize human susceptibility for an adverse outcome. We present a computational method that implements publicly available human genetic data to prioritize AOPs with potential for human genetic variability. We describe the application of this approach across multiple described AOPs for health outcomes of interest, and by focusing on a single molecular initiating event. This contributes to a long-term goal to improve estimates of human susceptibility for use in HHRA for single and multiple chemicals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.