ArticleEuropean radiology2018
How reliable are ADC measurements? A phantom and clinical study of cervical lymph nodes.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Quantitative diffusion magnetic resonance imaging for prediction of human papillomavirus status in head and neck squamous-cell carcinoma: A systematic review and meta-analysis.The neuroradiology journal · 2019Pooled it
- Apparent Diffusion Coefficient for Distinguishing Between Malignant and Benign Lesions in the Head and Neck Region: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2019Pooled it
- Open-source quality assurance for multi-parametric MRI: a diffusion analysis update for the magnetic resonance biomarker assessment software (MR-BIAS).Magma (New York, N.Y.) · 2025Article
- Multi-center and multi-vendor evaluation study across 1.5 T and 3 T scanners (part 1): apparent diffusion coefficient standardization in a diffusion MRI phantom.Magma (New York, N.Y.) · 2025Article
- Neuroanatomical Changes in the Stopping Network Across the Adult Lifespan Assessed With Quantitative and Diffusion MRI.Human brain mapping · 2025Article
- Evaluating Reproducibility of the ADC and Distortion in Diffusion-weighted Imaging (DWI) with Reverse Encoding Distortion Correction (RDC).Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Prostate magnetic resonance imaging (MRI) in patients with hip implants-presetting a protocol using a phantom.Quantitative imaging in medicine and surgery · 2024Article
- Robustness of apparent diffusion coefficient-based lymph node classification for diagnosis of prostate cancer metastasis.European radiology · 2024Article
- Delivering a Quantitative Imaging Agenda.Cancers · 2023Article
- Direct jet coaxial electrospinning of axon-mimicking fibers for diffusion tensor imaging.Polymers for advanced technologies · 2023Article
- Distinguishing mesorectal tumor deposits from metastatic lymph nodes by using diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging in rectal cancer.European radiology · 2023Article
- Preoperative Localization of Parathyroid Adenomas with Diffusion MR Imaging: Readout-segmented versus Single-shot Echo-planar Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Article
- Comparison of TGSE-BLADE DWI, RESOLVE DWI, and SS-EPI DWI in healthy volunteers and patients after cerebral aneurysm clipping.Scientific reports · 2022Article
- Apparent diffusion coefficient values in Modic changes - interobserver reproducibility and relation to Modic type.BMC musculoskeletal disorders · 2022Article
- Conformance of a 3T radiotherapy MRI scanner to the QIBA Diffusion Profile.Medical physics · 2022Article
- Quantitative MRI of Pancreatic Cystic Lesions: A New Diagnostic Approach.Healthcare (Basel, Switzerland) · 2022Article
- Temporal and sequence-related variability in diffusion-weighted imaging of presumed cerebrovascular accidents in the dog brain.Frontiers in veterinary science · 2022Article
- Whole-body diffusion-weighted MRI of normal lymph nodes: prospective apparent diffusion coefficient histogram and nodal distribution analysis in a healthy cohort.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Whole-body diffusion-weighted MRI in lymphoma-comparison of global apparent diffusion coefficient histogram parameters for differentiation of diseased nodes of lymphoma patients from normal lymph nodes of healthy individuals.Quantitative imaging in medicine and surgery · 2021Article
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4 authors at 1 institution in 1 country.
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Abstract
objectiveTo assess the reliability of ADC measurements in vitro and in cervical lymph nodes of healthy volunteers.
methodsWe used a GE 1.5 T MRI scanner and a first ice-water phantom according to recommendations released by the Quantitative Imaging Biomarker Alliance (QIBA) for assessing ADC against reference values. We analysed the target size effect by using a second phantom made of six inserted spheres with diameters ranging from 10 to 37 mm. Thirteen healthy volunteers were also scanned to assess the inter- and intra-observer reproducibility of volumetric ADC measurements of cervical lymph nodes.
resultsOn the ice-water phantom, the error in ADC measurements was less than 4.3 %. The spatial bias due to the non-linearity of gradient fields was found to be 24 % at 8 cm from the isocentre. ADC measure reliability decreased when addressing small targets due to partial volume effects (up to 12.8 %). The mean ADC value of cervical lymph nodes was 0.87.10
conclusionADC is a potentially important imaging biomarker in oncology; however, variability issues preclude its broader adoption. Reliable use of ADC requires technical advances and systematic quality control. KEY POINTS: • ADC is a promising quantitative imaging biomarker. • ADC has a fair inter-reader variability and good intra-reader variability. • Partial volume effect, post-processing software and non-linearity of scanners are limiting factors. • No threshold values for detecting cervical lymph node malignancy can be drawn.
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