Evidence map›Paper›PMID 29476167›Full record

ArticleEuropean journal of human genetics : EJHG2018

A novel variant associated with HDL-C levels by modifying DAGLB expression levels: An annotation-based genome-wide association study.

Dan Zhou, Dandan Zhang, Xiaohui Sun, Zhiqiang Li, Yaqin Ni, Zhongyan Shan, Hong Li, Chengguo Liu, Shuai Zhang, Yi Liu and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of human genetics : EJHG, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Druggable Targets in Endocannabinoid Signaling.Advances in experimental medicine and biology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Dan ZhouDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, 310058, China.
Dandan ZhangDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Xiaohui SunDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, 310058, China.
Zhiqiang LiThe Affiliated Hospital of Qingdao University & The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, 266000, China.ORCID http://orcid.org/0000-0002-0174-9254
Yaqin NiDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, 310058, China.
Zhongyan ShanThe Endocrine Institute and Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, China.
Hong LiDepartment of Endocrinology, Sir Run Run Shaw Hospital Affiliated to School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310020, China.
Chengguo LiuPutuo District People's Hospital, Zhoushan, Zhejiang, 316100, China.
Shuai ZhangDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Yi LiuDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, 310058, China.
Ruizhi ZhengDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, 310058, China.
Feixia PanDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, 310058, China.
Yimin ZhuDepartment of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, 310058, China. zhuym@zju.edu.cn.
Yongyong ShiThe Affiliated Hospital of Qingdao University & The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, 266000, China. shiyongyong@gmail.com.ORCID http://orcid.org/0000-0003-1710-1505
Maode LaiDepartment of Pathology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China. lmp@zju.edu.cn.
Zhejiang University · CNQingdao University · CNCentral Hospital of Putuo District · CNFirst Hospital of China Medical University · CNSir Run Run Shaw Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although numbers of genome-wide association studies (GWAS) have been performed for serum lipid levels, limited heritability has been explained. Studies showed that combining data from GWAS and expression quantitative trait loci (eQTLs) signals can both enhance the discovery of trait-associated SNPs and gain a better understanding of the mechanism. We performed an annotation-based, multistage genome-wide screening for serum-lipid-level-associated loci in totally 6863 Han Chinese. A serum high-density lipoprotein cholesterol (HDL-C) associated variant rs1880118 (hg19 chr7:g. 6435220G>C) was replicated (P

Indexed as

Genome-Wide Association StudyAllelesCholesterol, HDLFemaleGene Expression RegulationGenome, HumanGenotypeHaplotypesHumansLipid MetabolismLipoprotein LipaseMaleMolecular Sequence AnnotationPhenotypePolymorphism, Single NucleotideQuantitative Trait LociCholesterol, HDLDAGLB protein, humanLipoprotein Lipase

Identifiers

PMID29476167
PMCPMC5974016
OpenAlexW2790706374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.