Evidence map›Paper›PMID 29476166›Full record

ArticleEuropean journal of human genetics : EJHG2018

Intentions to share exome sequencing results with family members: exploring spousal beliefs and attitudes.

Erin Turbitt, Megan C Roberts, Rebecca A Ferrer, Jennifer M Taber, Katie L Lewis, Leslie G Biesecker, Barbara B Biesecker, William Mp Klein

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of human genetics : EJHG, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Erin TurbittSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes Health, Bethesda, MD, USA. erin.turbitt@nih.gov.ORCID http://orcid.org/0000-0002-6650-9702
Megan C RobertsBehavioral Research Program, National Cancer Institute, National Institutes Health, Bethesda, MD, USA.
Rebecca A FerrerBehavioral Research Program, National Cancer Institute, National Institutes Health, Bethesda, MD, USA.
Jennifer M TaberDepartment of Psychological Sciences, Kent State University, Kent, OH, USA.ORCID http://orcid.org/0000-0003-3285-4871
Katie L LewisMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes Health, Bethesda, MD, USA.
Leslie G BieseckerMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0197-3811
Barbara B BieseckerSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes Health, Bethesda, MD, USA.
William Mp KleinSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes Health, Bethesda, MD, USA.
National Human Genome Research Institute · USNational Institutes of Health · USKent State University · US

Funding

Genomic Ascertainment - Clinical and Behavioral AspectsZIAHG200387 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BIESECKER, LESLIE · 2013 to 2025
$15.5M
Interventions in Genetic CounselingZIAHG200317 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BIESECKER, BARBARA BOWLES · 2009 to 2018
$7.6M
6 · The paper itself

Abstract

Given familial implications of genetic information, it is important to understand intentions to share carrier results with family members. To our knowledge, no studies among individuals undergoing exome sequencing have used dyadic data analysis to examine the effect of spousal perceptions and beliefs. Survey responses from 136 individuals (68 couples) undergoing exome sequencing in a research study were analyzed using dyadic analysis (the actor-partner interdependence model). Intention to share carrier results with family members was correlated between spouses (ICC = 0.43; 95% CI: 0.21-0.61; p = 0.004), as was worry about risk of a genetic condition in the family (ICC = 0.45; 95% CI: 0.24-0.62; p < 0.001). Perceived value of result and worry about risk of a genetic condition in the family were associated with one's own intentions to share carrier results. However, spousal status on these variables did not explain additional variance in an individual's intentions. Although we found no partner effects on intentions, spouses have comparable intentions to share carrier results, suggesting it may be important to account for non-independence in other research studies.

Indexed as

HeterozygoteAdaptation, PsychologicalAgedExomeFamilyFemaleGenetic Carrier ScreeningHumansMaleMiddle AgedSequence Analysis, DNASpousesSurveys and QuestionnairesUnited States

Identifiers

PMID29476166
PMCPMC5945607
OpenAlexW2802207440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.