Evidence map›Paper›PMID 29476125›Full record

ArticleScientific reports2018

Nanodelivery of a functional membrane receptor to manipulate cellular phenotype.

Tommaso Patriarchi, Ao Shen, Wei He, Mo Baikoghli, R Holland Cheng, Yang K Xiang, Matthew A Coleman, Lin Tian

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Cationic HDL mimetics enhance in vivo delivery of self-replicating mRNA.Nanomedicine : nanotechnology, biology, and medicine · 2020
    Article
  7. BRAIN Initiative: Cutting-Edge Tools and Resources for the Community.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tommaso PatriarchiUniversity of California Davis, School of Medicine, Department of Biochemistry and Molecular Medicine, Davis, California, USA.
Ao ShenUniversity of California Davis, School of Medicine, Department of Pharmacology, Davis, California, USA.
Wei HeLawrence Livermore National Laboratory, Livermore, California, USA.
Mo BaikoghliUniversity of California Davis, Department of Molecular and Cellular Biology, California, USA.
R Holland ChengUniversity of California Davis, Department of Molecular and Cellular Biology, California, USA.ORCID 0000-0002-2068-7271
Yang K XiangUniversity of California Davis, School of Medicine, Department of Pharmacology, Davis, California, USA.ORCID 0000-0003-1786-9143
Matthew A ColemanLawrence Livermore National Laboratory, Livermore, California, USA. coleman16@llnl.gov.
Lin TianUniversity of California Davis, School of Medicine, Department of Biochemistry and Molecular Medicine, Davis, California, USA. lintian@ucdavis.edu.
University of California, Davis · USLawrence Livermore National Laboratory · USVA Northern California Health Care System · US

Funding

The rodent eye as a non-invasive window for understanding cancer nanotherapeuticsU01CA198880 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LAM, KIT S · 2015 to 2019
$2.9M
Insulin Inhibition of beta-AR Signaling in the MyocardiumR01HL127764 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$2.4M
Fluorescent biosensors for imaging neurotransmitters: observing synapses in actioDP2MH107056 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN · 2014 to 2014
$2.3M
Characterization of Erbb Receptors in NanoparticlesR01CA155642 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COLEMAN, MATTHEW ADRIAN, HENDERSON, PAUL THOMAS · 2011 to 2015
$1.6M
Cardiac Dysfunction in the Met Syndrome: Cross-talk between IR and bAR SignalingR01HL112413 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$1.6M
Genetically encoded sensors for the biogenic amine: watching neuromodulation in actionU01NS090604 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN · 2014 to 2016
$1.3M
Genetically Encoded Small Illuminants for 4D nucleome imagingU01EB021230 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHENG, R.HOLLAND, IZUMIYA, YOSHIHIRO · 2015 to 2017
$990k
Present Homologous and Heterologous Antigen with Hepatitis E VirusR56AI095382 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHENG, R.HOLLAND · 2012 to 2012
$385k
Molecular mechanisms of Insulin resistance under chronic stressI01BX002900 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI XIANG, YANG K · 2016 to 2021
–
BLRD VA I01 BX002900NCI NIH HHS R01 CA155642NCI NIH HHS U01 CA198880NHLBI NIH HHS R01 HL112413NHLBI NIH HHS R01 HL127764NIAID NIH HHS R56 AI095382NIBIB NIH HHS U01 EB021230NIMH NIH HHS DP2 MH107056NINDS NIH HHS U01 NS090604
6 · The paper itself

Abstract

Modification of membrane receptor makeup is one of the most efficient ways to control input-output signals but is usually achieved by expressing DNA or RNA-encoded proteins or by using other genome-editing methods, which can be technically challenging and produce unwanted side effects. Here we develop and validate a nanodelivery approach to transfer in vitro synthesized, functional membrane receptors into the plasma membrane of living cells. Using β

Indexed as

Cell MembraneDNAHumansNanomedicineNanoparticlesPhenotypeReceptors, Adrenergic, beta-2Receptors, Cytoplasmic and NuclearRNASynthetic BiologyWound HealingDNAReceptors, Adrenergic, beta-2Receptors, Cytoplasmic and NuclearRNA

Identifiers

PMID29476125
PMCPMC5824837
OpenAlexW2794045875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.