ArticleScientific reports2018
Shuang-Huang-Lian injection induces an immediate hypersensitivity reaction via C5a but not IgE.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- The Anaphylactic and Anti-allergenic Properties of Shuanghuanglian: A Review.Combinatorial chemistry & high throughput screening · 2026Review
- Safflower yellow inChinese herbal medicines · 2026Article
- Advances in MRGPRX2-mediated anaphylactoid reactions to traditional Chinese medicine injections.Frontiers in pharmacology · 2025Review
- A Diboronic Acid-Based Fluorescent Sensor Array for Rapid Identification of Lonicerae Japonicae Flos and Lonicerae Flos.Molecules (Basel, Switzerland) · 2024Article
- Modulation of the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2) by Xenobiotic Compounds and Its Relevance to Human Diseases.Journal of xenobiotics · 2024Review
- Tea for histamine anti-allergy: component analysis of tea extracts and potential mechanism for treating histamine anti-allergy.Frontiers in pharmacology · 2024Article
- Pseudo-allergic reactions induced by Chinese medicine injections: a review.Chinese medicine · 2023Review
- Classification and Authentication of Lonicerae Japonicae Flos and Lonicerae Flos by UsingMolecules (Basel, Switzerland) · 2023Article
- Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dualFrontiers in pharmacology · 2022Article
- Anaphylaxis effect and substance basis of honeysuckle extract.Chinese herbal medicines · 2021Article
- Review
- Compound Kushen Injection Induces Immediate Hypersensitivity Reaction Through Promoting the Production of Platelet-Activating Factor viaFrontiers in pharmacology · 2021Article
- Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients.Acta pharmacologica Sinica · 2020Article
- Penicillin causes non-allergic anaphylaxis by activating the contact system.Scientific reports · 2020Article
- Sodium aescinate and its bioactive components induce degranulation via oxidative stress in RBL-2H3 mast cells.Toxicology research · 2020Article
- Macromolecular substances as a dangerous factor in traditional Chinese medicine injections were determined by size-exclusive chromatography.Toxicology research · 2020Article
- Lonicerae japonicae flos and Lonicerae flos: a systematic review of ethnopharmacology, phytochemistry and pharmacology.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2020Review
- Forsythoside A and Forsythoside B Contribute to Shuanghuanglian Injection-Induced Pseudoallergic Reactions through the RhoA/ROCK Signaling Pathway.International journal of molecular sciences · 2019Article
- Qing-Kai-Ling Injection Induces Immediate Hypersensitivity ReactionFrontiers in pharmacology · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among traditional Chinese medicine injections, intravenous Shuang-Huang-Lian (IV-SHL) has the highest incidence of injection-induced immediate hypersensitivity reactions (IHRs). The precise mechanisms of IV-SHL-induced IHRs remain ambiguous. In this study, we investigated the mechanisms of SHL injection (SHLI)-induced IHRs. Our data showed that serum total IgE and mouse mast cell protease 1 (MMCP1) levels were higher in the SHLI antiserum; however, these effects of SHLI disappeared in the antibiotic-treated mice. SHLI caused intraplantar vasopermeability and shock during the first local or systemic injection. SHLI-induced nonallergic IHRs were attributed to its intermediate fraction F2 (the extract of Lonicerae Japonicae Flos and Fructus forsythiae), and could be blocked by antagonists for histamine or C5a, rather than PAF or C3a. Eight constituents of F2 were able to directly activate C5 to promote local vasopermeability at the mg/mL level. In conclusion, SHLI-induced IHRs are not mediated by IgE. SHLI or its F2 can directly activate blood C5. Subsequently, C5a is likely to provoke histamine release from its effector cells (e.g., mast cells and basophils), indicating that histamine is a principal effector of IHRs induced by SHLI.
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