Evidence map›Paper›PMID 29476110›Full record

ArticleScientific reports2018

A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis.

Michael D Weston, Shikha Tarang, Marsha L Pierce, Umesh Pyakurel, Sonia M Rocha-Sanchez, JoAnn McGee, Edward J Walsh, Garrett A Soukup

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. NcRNA: key and potential in hearing loss.Frontiers in neuroscience · 2023
    Review
  7. Article
  8. Hearing impairment due toDisease models & mechanisms · 2020
    Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Michael D WestonDepartment of Oral Biology, School of Dentistry, Creighton University, 780729 California Plaza, Omaha, NE 68178-0729, USA. michaelweston@creighton.edu.
Shikha TarangDepartment of Oral Biology, School of Dentistry, Creighton University, 780729 California Plaza, Omaha, NE 68178-0729, USA.
Marsha L PierceDepartment of Pharmacology, School of Medicine, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Umesh PyakurelDepartment of Oral Biology, School of Dentistry, Creighton University, 780729 California Plaza, Omaha, NE 68178-0729, USA.
Sonia M Rocha-SanchezDepartment of Oral Biology, School of Dentistry, Creighton University, 780729 California Plaza, Omaha, NE 68178-0729, USA.
JoAnn McGeeDevelopmental Auditory Physiology Laboratory, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA.
Edward J WalshDevelopmental Auditory Physiology Laboratory, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA.
Garrett A SoukupDepartment of Biomedical Sciences, School of Medicine, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Creighton University · USBoys Town · USBoys Town National Research Hospital · US

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Apar Kishor Ganti · 1985 to 2026
$55.0M
TRANSGENIC EXPRESSION ANALYSIS OF MIRNA-144P20RR018788 · NCRR · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HAIDER, NEENA B · 2003 to 2011
$16.5M
UNMC Histology/Imaging and Creighton University Imaging Core FacilityP30GM110768 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SMITH, SHELLEY D · 2014 to 2018
$5.1M
Research Pilot Project ProgramP30GM106397 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI JOHNSON, KEITH R · 2013 to 2017
$4.9M
The Molecular Biology of Neurosurgery SystemsP20GM103471 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SMITH, SHELLEY D · 2012 to 2013
$4.1M
Replacing an Animal Resource Facility Cage Washer.G20RR024001 · NCRR · CREIGHTON UNIVERSITY · PI DRESCHER, KRISTEN · 2007 to 2007
$638k
MicroRNAs and RNA Interference Effects on Hair Cell TransdifferentiationR15DC014813 · NIDCD · CREIGHTON UNIVERSITY · PI WESTON, MICHAEL D · 2016 to 2016
$437k
Characterization of a Temporally Controlled Dominant-Negative RB1 Mouse ModelR21OD019745 · OD · CREIGHTON UNIVERSITY · PI ROCHA-SANCHEZ, SONIA M · 2015 to 2016
$417k
MicroRNA expression in mouse ear developmentF32DC008253 · NIDCD · CREIGHTON UNIVERSITY · PI WESTON, MICHAEL D · 2007 to 2008
$104k
NCI NIH HHS P30 CA036727NCRR NIH HHS G20 RR024001NCRR NIH HHS P20 RR018788NIDCD NIH HHS F32 DC008253NIDCD NIH HHS R15 DC014813NIGMS NIH HHS P20 GM103471NIGMS NIH HHS P30 GM106397NIGMS NIH HHS P30 GM110768NIH HHS R21 OD019745
6 · The paper itself

Abstract

Germline mutations in Mir96, one of three co-expressed polycistronic miRNA genes (Mir96, Mir182, Mir183), cause hereditary hearing loss in humans and mice. Transgenic FVB/NCrl- Tg(GFAP-Mir183,Mir96,Mir182)MDW1 mice (Tg

Indexed as

AnimalsCell DifferentiationDisease Models, AnimalEar, InnerGene Expression RegulationHair Cells, Auditory, InnerHearing Loss, SensorineuralHomeostasisHumansMiceMice, TransgenicMicroarray AnalysisMicroRNAsRNA, MessengerMicroRNAsMirn182 microRNA, mouseMirn183 microRNA, mouseMirn96 microRNA, mouseRNA, Messenger

Identifiers

PMID29476110
PMCPMC5824881
OpenAlexW2788766645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.