ArticleScientific reports2018
STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles.
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Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- A Phase II Window of Opportunity Study of Neoadjuvant PD-L1 versus PD-L1 plus CTLA-4 Blockade for Patients with Malignant Pleural Mesothelioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Trial
- Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis.The Journal of clinical investigation · 2020Trial
- Molecular Signature and miRNA Pattern of CD4 + T Lymphocytes in Plaque Psoriasis.Clinical reviews in allergy & immunology · 2026Review
- Bcl6 expression is associated with a distinct immune landscape and spatial transcriptome in COVID-19.JCI insight · 2025Article
- Aberrant T-cell phenotypes in a cohort of patients with post-treatment Lyme disease.Frontiers in immunology · 2025Article
- Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus.Frontiers in immunology · 2025Article
- Oligoclonal CD4Communications biology · 2024Article
- Clinical utility of measuring CD4Journal of autoimmunity · 2023Article
- IL-7 producing immunotherapy improvesHuman vaccines & immunotherapeutics · 2023Article
- CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4Cellular & molecular immunology · 2023Article
- Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children.Nature immunology · 2023Article
- Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children.Research square · 2022Article
- The deficiency in Th2-like Tfh cells affects the maturation and quality of HIV-specific B cell response in viremic infection.Frontiers in immunology · 2022Article
- Using Mass Cytometry to Address Tfh and Tfr Heterogeneity.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Live-Attenuated Influenza Vaccine Induces Tonsillar Follicular T Helper Cell Responses That Correlate With Antibody Induction.The Journal of infectious diseases · 2020Article
- STAT3, a Master Regulator of Anti-Tumor Immune Response.Cancers · 2019Review
- Follicular regulatory T cells inhibit the development of granzyme B-expressing follicular helper T cells.JCI insight · 2019Article
- T follicular helper cells in human efferent lymph retain lymphoid characteristics.The Journal of clinical investigation · 2019Article
- Recurrent group AScience translational medicine · 2019Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
Jalila AlshekailiDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.ORCID 0000-0002-2576-4766
Rochna ChandDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.
Cindy Eunhee LeeDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.
Susan CorleySystems Biology Initiative, School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, Australia.ORCID 0000-0003-0605-6411
Kristy KwongDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.
Ilenia PapaDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.
David A FulcherDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.
Katrina L RandallDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.
Jennifer W LeidingDivision of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of South Florida and Johns Hopskins All Children's Hospital, St Petersburg, Florida, USA.
Cindy S MaImmunology Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia.
Marc R WilkinsSystems Biology Initiative, School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, Australia.
Gulbu UzelLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Chris C GoodnowDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.ORCID 0000-0001-5296-6155
Carola G VinuesaDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.
Stuart G TangyeImmunology Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia.ORCID 0000-0002-5360-5180
Matthew C CookDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia. matthew.cook@anu.edu.au.ORCID 0000-0002-3331-9363
Australian National University · AUGarvan Institute of Medical Research · AUUNSW Sydney · AUJohns Hopkins University · USNational Institutes of Health · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1
Indexed as
Case-Control StudiesCD57 AntigensCell ProliferationCytotoxicity, ImmunologicGene Expression RegulationHumansImmunophenotypingInterleukin-10Interleukin-21InterleukinsPalatine TonsilPhenotypePrimary Cell CultureProgrammed Cell Death 1 ReceptorSignal TransductionSTAT3 Transcription FactorCD57 AntigensIL10 protein, humanInterleukin-10Interleukin-21InterleukinsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorSTAT3 protein, humanSTAT3 Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.